Trial reportThe Journal of clinical endocrinology and metabolism2009
Impact of growth hormone receptor blockade on substrate metabolism during fasting in healthy subjects.
Trial report in The Journal of clinical endocrinology and metabolism, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02152124 (Growth Hormone, IGF-1 and Medical Treatment in Acromegaly), which is not on this map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Growth Hormone, IGF-1 and Medical Treatment in Acromegaly: Are There Effects on Gut Hormone Physiology and Postprandial Substrate Metabolism?
Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- Reduction in visceral adiposity is associated with an improved metabolic profile in HIV-infected patients receiving tesamorelin.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2012Trial
- Nonalcoholic Fatty Liver Disease and Endocrine Axes-A Scoping Review.Metabolites · 2022Article
- Role of pulsatile growth hormone (GH) secretion in the regulation of lipolysis in fasting humans.Clinical diabetes and endocrinology · 2022Article
- Review
- Growth hormone directly favors hepatic ketogenesis in persons with prediabetes or type 2 diabetes mellitus treated with empagliflozin.Endocrine · 2021Article
- Prepartum and Postpartum Feed Restrictions Affect Blood Metabolites and Hormones Reducing Colostrum and Milk Yields in Fat-Tailed Dairy Sheep.Animals : an open access journal from MDPI · 2021Article
- Body Composition Changes with Long-term Pegvisomant Therapy of Acromegaly.Journal of the Endocrine Society · 2021Article
- Growth hormone controls lipolysis by regulation of FSP27 expression.The Journal of endocrinology · 2018Article
- Adult-Onset Hepatocyte GH Resistance Promotes NASH in Male Mice, Without Severe Systemic Metabolic Dysfunction.Endocrinology · 2018Article
- Adipocyte STAT5 deficiency promotes adiposity and impairs lipid mobilisation in mice.Diabetologia · 2017Article
- Complications of acromegaly: cardiovascular, respiratory and metabolic comorbidities.Pituitary · 2017Review
- Article
- Effects of a Pre-Exercise Meal on Plasma Growth Hormone Response and Fat Oxidation during Walking.Preventive nutrition and food science · 2013Article
- Extra-hepatic Acromegaly.European endocrinology · 2013Review
- The rise in growth hormone during starvation does not serve to maintain glucose levels or lean mass but is required for appropriate adipose tissue response in female mice.Endocrinology · 2013Article
- Does the pituitary somatotrope play a primary role in regulating GH output in metabolic extremes?Annals of the New York Academy of Sciences · 2011Review
- Effects of a growth hormone-releasing hormone analog on endogenous GH pulsatility and insulin sensitivity in healthy men.The Journal of clinical endocrinology and metabolism · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
contextExperimental studies in GH-deficient patients and in healthy subjects receiving somatostatin-infusion suggest that GH is an important regulator of substrate metabolism during fasting. These models may not adequately reflect the selective effects of GH, and GH receptor (GHR) blockade offers a new model to define the metabolic role of GH.
objectiveThe aim of this study was to investigate the impact of GHR blockade on substrate metabolism and insulin sensitivity during fasting.
designWe conducted a randomized, placebo-controlled, crossover study in 10 healthy young men.
interventionAfter 36 h of fasting with saline or pegvisomant (GHR blockade), the subjects were studied during a 4-h basal period and 2.5-h hyperinsulinemic euglycemic clamp. MAIN OUTCOME: We measured whole-body and forearm glucose, lipid, and protein metabolism, peripheral insulin sensitivity, and acyl and desacyl ghrelin.
resultsGHR blockade significantly suppressed circulating free fatty acids (1226 +/- 83 vs. 1074 +/- 65 micromol/liter; P = 0.03) and ketone bodies (3080 +/- 271 vs. 2015 +/- 235 micromol/liter; P <or= 0.01), as well as forearm uptake of free fatty acids (0.341 +/- 0.150 vs. 0.004 +/- 0.119 micromol/100 ml x min; P < 0.01) and lipid oxidation (1.3 +/- 0.1 vs. 1.2 +/- 0.1 mg/kg x min; P = 0.03) in the basal period. By contrast, IGF-I levels in either serum or peripheral tissues were not impacted by GHR blockade, and protein metabolism was also unaffected. Basal glucose levels were elevated by GHR blockade, but insulin sensitivity was similar; this was associated with an increased acyl/desacyl ghrelin ratio.
conclusionGHR blockade, without changes in circulating or tissue IGF-I levels, selectively suppresses lipid mobilization and oxidation after short-term fasting. This supports the notion that stimulation of lipolysis is a primary and important effect of GH.
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