ArticleJournal of affective disorders2010
A genome-wide linkage study of bipolar disorder and co-morbid migraine: replication of migraine linkage on chromosome 4q24, and suggestion of an overlapping susceptibility region for both disorders on chromosome 20p11.
Article in Journal of affective disorders, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Understanding the nature of psychiatric comorbidity in migraine: a systematic review focused on interactions and treatment implications.The journal of headache and pain · 2019Pooled it
- Meta-analysis of genome-wide association for migraine in six population-based European cohorts.European journal of human genetics : EJHG · 2011Pooled it
- Therapeutic Overlap Between Bipolar Disorder and Migraine: A Systematic Review of Pharmacological Trials.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Risk of major mental disorders in the offspring of parents with migraine.Annals of general psychiatry · 2024Article
- A population-health approach to characterizing migraine by comorbidity: Results from the Mindfulness and Migraine Cohort Study.Cephalalgia : an international journal of headache · 2022Article
- Lithium use associated with symptom severity in comorbid bipolar disorder I and migraine.Brain and behavior · 2022Article
- Comorbid Bipolar Disorder and Migraine: From Mechanisms to Treatment.Frontiers in psychiatry · 2020Review
- Financial Stress Interacts WithFrontiers in behavioral neuroscience · 2019Article
- Parental and comorbid migraine in individuals with bipolar disorder: A nationwide register study.Journal of affective disorders · 2016Article
- Rapid cycling as a feature of bipolar disorder and comorbid migraine.Journal of affective disorders · 2015Article
- Genetic influences on response to novel objects and dimensions of personality in Papio baboons.Behavior genetics · 2015Article
- Studies on the pathophysiology and genetic basis of migraine.Current genomics · 2013Article
- A bivariate mann-whitney approach for unraveling genetic variants and interactions contributing to comorbidity.Genetic epidemiology · 2013Article
- Genetic variants affecting the neural processing of human facial expressions: evidence using a genome-wide functional imaging approach.Translational psychiatry · 2012Article
- Confirmation that Xq27 and Xq28 are susceptibility loci for migraine in independent pedigrees and a case-control cohort.Neurogenetics · 2012Article
- Bipolar affective disorder and migraine.Case reports in medicine · 2012Article
- White matter hyperintensities: from medical comorbidities to bipolar disorders and back.Annals of medicine · 2011Review
- Adult attention deficit hyperactivity disorder is associated with migraine headaches.European archives of psychiatry and clinical neuroscience · 2011Article
- Article
- A genome-wide association study of bipolar disorder and comorbid migraine.Genes, brain, and behavior · 2010Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
Migraine and Bipolar Disorder (BPAD) are clinically heterogeneous disorders of the brain with a significant, but complex, genetic component. Epidemiological and clinical studies have demonstrated a high degree of co-morbidity between migraine and BPAD. Several genome-wide linkage studies in BPAD and migraine have shown overlapping regions of linkage on chromosomes, and two functionally similar voltage-dependent calcium channels CACNA1A and CACNA1C have been identified in familial hemiplegic migraine and recently implicated in two whole genome BPAD association studies, respectively. We hypothesized that using migraine co-morbidity to look at subsets of BPAD families in a genetic linkage analysis would prove useful in identifying genetic susceptibility regions in both of these disorders. We used BPAD with co-morbid migraine as an alternative phenotype definition in a re-analysis of the NIMH Bipolar Genetics Initiative wave 4 data set. In this analysis we selected only those families in which at least two members were diagnosed with migraine by a doctor according to patients' reports. Nonparametric linkage analysis performed on 31 families segregating both BPAD and migraine identified a linkage signal on chromosome 4q24 for migraine (but not BPAD) with a peak LOD of 2.26. This region has previously been implicated in two independent migraine linkage studies. In addition we identified a locus on chromosome 20p11 with overlapping elevated LOD scores for both migraine (LOD=1.95) and BPAD (LOD=1.67) phenotypes. This region has previously been implicated in two BPAD linkage studies, and, interestingly, it harbors a known potassium dependant sodium/calcium exchanger gene, SLC24A3, that plays a critical role in neuronal calcium homeostasis. Our findings replicate a previously identified migraine linkage locus on chromosome 4 (not co-segregating with BPAD) in a sample of BPAD families with co-morbid migraine, and suggest a susceptibility locus on chromosome 20, harboring a gene for the migraine/BPAD phenotype. Together these data suggest that some genes may predispose to both bipolar disorder and migraine.
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