Evidence map›Paper›PMID 19819542›Full record

ReviewLancet (London, England)2009

Autism.

Susan E Levy, David S Mandell, Robert T Schultz

Erratum issued 2 registry-linked trialsOpen access · greenAbstract readReview
In one paragraph

Review in Lancet (London, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 286 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
286citing papers in PubMed, 7 pooled it
22.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02746445 completednot on this mapstarted 2016, after this paper: background citation

A Longitudinal Study on the Safety and Efficacy for Subjects With Autism Spectrum Disorder (ASD) Who Received Magnetic EEG/ECG-Guided Resonance Therapy (MeRT)

TypeobservationalSponsorWave NeuroscienceRan2016 to 2017Enrolled11ConditionsAutistic DisorderArmsNo intervention
NCT02758496 completednot on this mapstarted 2016, after this paper: background citation

A Chart Review to Evaluate the Safety and Efficacy of Magnetic EEG/ECG-Guided Resonance Therapy (MeRT) on Subjects With Autism Spectrum Disorder (ASD)

TypeobservationalSponsorWave NeuroscienceRan2016 to 2017Enrolled141ConditionsAutistic DisorderArmsMeRT Efficacy Chart Review
3 · Its place in the literature

Who cites it

286 citing papers in PubMed, 7 syntheses or guidelines pooled it, 647 citations in OpenAlex.

  1. Pooled it
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  5. A Meta-Analysis of Maternal Smoking during Pregnancy and Autism Spectrum Disorder Risk in Offspring.International journal of environmental research and public health · 2015
    Pooled it
  6. Visuo-spatial performance in autism: a meta-analysis.Journal of autism and developmental disorders · 2014
    Pooled it
  7. Pooled it
  8. A Randomized, Crossover Trial of a Novel Sound-to-Sleep Mattress Technology in Children with Autism and Sleep Difficulties.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2017
    Trial
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226 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Susan E LevyChildren's Hospital of Philadelphia, University of Pennsylvania, School of Medicine, Center for Autism Research, Philadelphia, PA 19104, USA. levys@email.chop.edu
David S Mandell
Robert T Schultz
Center for Autism and Related Disorders · USUniversity of Pennsylvania · US

Funding

Cellular and molecular mechanisms governing cortical surface area overgrowth in iPSC-derived neural cells from longitudinally characterized individuals with autismR01HD055741 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph Piven · 2007 to 2026
$52.6M
Early Autism Risk Longitudinal Investigation (EARLI) NetworkR01ES016443 · NIEHS · DREXEL UNIVERSITY · PI NEWSCHAFFER, CRAIG J · 2008 to 2013
$15.6M
National CADDRE Study: Child Development and AutismU10DD000182 · DD · UNIVERSITY OF PENNSYLVANIA · PI PINTO-MARTIN, JENNIFER A · 2006 to 2010
$5.8M
Electrophysiological Signatures of Language Impairment in Autism Spectrum DisordeR01DC008871 · NIDCD · CHILDREN'S HOSP OF PHILADELPHIA · PI ROBERTS, TIMOTHY P · 2007 to 2018
$3.6M
Interstate Variation in Healthcare Utilization Among Children with ASDR01MH077000 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI MANDELL, DAVID S · 2007 to 2011
$2.8M
Language Functioning Optimal Outcome Children--AutismR01MH076189 · NIMH · UNIVERSITY OF CONNECTICUT STORRS · PI FEIN, DEBORAH A. · 2006 to 2009
$2.0M
The fusiform and amygalda in the pathobiology of autismR01MH073084 · NIMH · YALE UNIVERSITY · PI SCHULTZ, ROBERT THOMAS · 2005 to 2009
$1.6M
A Randomized Trial of the STAR Program for Children with Autism Spectrum DisorderR01MH083717 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI MANDELL, DAVID S · 2008 to 2009
$1.4M
The Epidemiology of Autism in a Low Birthweight CohortR01MH073807 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI PINTO-MARTIN, JENNIFER A · 2006 to 2008
$1.0M
Understanding the Delay in the Diagnosis of AutismK01MH067628 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI MANDELL, DAVID S · 2005 to 2009
$671k
NCBDD CDC HHS 1-U10-DD-000182-03NCBDD CDC HHS U10 DD000182NICHD NIH HHS 1 P50 HD055726-01NICHD NIH HHS 1 R01 HD055741-01NICHD NIH HHS R01 HD055741NIDCD NIH HHS 1-R01-DC008871-01NIDCD NIH HHS R01 DC008871NIEHS NIH HHS R01 ES016443NIEHS NIH HHS R01 ES016443-01NIMH NIH HHS 1K01MH067628-1NIMH NIH HHS 1-R01-MH-073807NIMH NIH HHS 1 R01 MH077000-01NIMH NIH HHS 1 R01 MH083717-01A1NIMH NIH HHS 5R01MH073084NIMH NIH HHS 5R01MH076189-03NIMH NIH HHS K01 MH067628NIMH NIH HHS R01 MH073084NIMH NIH HHS R01 MH073807NIMH NIH HHS R01 MH077000NIMH NIH HHS R01 MH083717
6 · The paper itself

Abstract

Autism spectrum disorders are characterised by severe deficits in socialisation, communication, and repetitive or unusual behaviours. Increases over time in the frequency of these disorders (to present rates of about 60 cases per 10,000 children) might be attributable to factors such as new administrative classifications, policy and practice changes, and increased awareness. Surveillance and screening strategies for early identification could enable early treatment and improved outcomes. Autism spectrum disorders are highly genetic and multifactorial, with many risk factors acting together. Genes that affect synaptic maturation are implicated, resulting in neurobiological theories focusing on connectivity and neural effects of gene expression. Several treatments might address core and comorbid symptoms. However, not all treatments have been adequately studied. Improved strategies for early identification with phenotypic characteristics and biological markers (eg, electrophysiological changes) might hopefully improve effectiveness of treatment. Further knowledge about early identification, neurobiology of autism, effective treatments, and the effect of this disorder on families is needed.

Indexed as

Autistic DisorderBehavior TherapyCausalityChildChild, PreschoolCommunicationComorbidityDiagnosis, DifferentialEarly DiagnosisEarly Intervention, EducationalForecastingGenetic Predisposition to DiseaseGenetic VariationHumansMagnetic Resonance ImagingMass Screening

Identifiers

PMID19819542
PMCPMC2863325
OpenAlexW4211261982

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.