SynthesisBiological psychiatry2010
Meta-analysis of 15 genome-wide linkage scans of smoking behavior.
Synthesis in Biological psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence.Translational psychiatry · 2015Pooled it
- Association of CHRNA4 polymorphisms with smoking behavior in two populations.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2011Pooled it
- Organic cation transporter variation and response to smoking cessation therapies.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2014Trial
- Trial
- Combining neuroimaging and brain stimulation to test alternative causal pathways for nicotine addiction in schizophrenia.Brain stimulationTrial
- A mode of action protein based approach that characterizes the relationships among most major diseases.Scientific reports · 2025Article
- Prospects for finding the mechanisms of sex differences in addiction with human and model organism genetic analysis.Genes, brain, and behavior · 2020Review
- Prediction of Smoking Behavior From Single Nucleotide Polymorphisms With Machine Learning Approaches.Frontiers in psychiatry · 2020Article
- A regulatory variant of CHRM3 is associated with cannabis-induced hallucinations in European Americans.Translational psychiatry · 2019Article
- An Exome-Wide Association Study Identifies New Susceptibility Loci for Age of Smoking Initiation in African- and European-American Populations.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019Article
- Genome-wide association study in Finnish twins highlights the connection between nicotine addiction and neurotrophin signaling pathway.Addiction biology · 2019Article
- A Novel Tobacco Use Phenotype Suggests the 15q25 and 19q13 Loci May be Differentially Associated With Cigarettes per Day and Tobacco-Related Problems.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2017Article
- GRONS: a comprehensive genetic resource of nicotine and smoking.Database : the journal of biological databases and curation · 2017Article
- Genome-wide significant loci for addiction and anxiety.European psychiatry : the journal of the Association of European Psychiatrists · 2016Article
- Converging findings from linkage and association analyses on susceptibility genes for smoking and other addictions.Molecular psychiatry · 2016Review
- Smokescreen: a targeted genotyping array for addiction research.BMC genomics · 2016Article
- Gene by Environment Investigation of Incident Lung Cancer Risk in African-Americans.EBioMedicine · 2016Article
- Prioritizing Genes Related to Nicotine Addiction Via a Multi-source-Based Approach.Molecular neurobiology · 2015Article
- Role of the Neuregulin Signaling Pathway in Nicotine Dependence and Co-morbid Disorders.International review of neurobiology · 2015Review
- Genetic Association of CHRNB3 and CHRNA6 Gene Polymorphisms with Nicotine Dependence Syndrome Scale in Korean Population.Psychiatry investigation · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundA genetic contribution to smoking behavior is well-established. To identify loci that increase the risk for smoking behavior, many genome-wide linkage scans have been performed with various smoking behavior assessments. Numerous putative susceptibility loci have been identified, but only a few of these were replicated in independent studies.
methodsWe used genome search meta-analysis (GSMA) to identify risk loci by pooling all available independent genome scan results on smoking behavior. Additionally, to minimize locus heterogeneity, subgroup analyses of the smoking behavior assessed by the Fagerstrom Test for Nicotine Dependence (FTND) and maximum number of cigarettes smoked in a 24-hour period (MaxCigs24) were carried out. Samples of European ancestry were also analyzed separately.
resultsA total number of 15 genome scan results were available for analysis, including 3404 families with 10,253 subjects. Overall, the primary GSMA across all smoking behavior identified a genome-wide suggestive linkage in chromosome 17q24.3-q25.3 (p(SR) = .001). A secondary analysis of FTND in European-ancestry samples (625 families with 1878 subjects) detected a genome-wide suggestive linkage in 5q33.1-5q35.2 (p(SR) = .0076). Subgroup analysis of MaxCigs24 (966 families with 3273 subjects) identified a genome-wide significant linkage in 20q13.12-q13.32 (p(SR) = .00041, p(OR) = .048), where a strongly supported nicotine dependence candidate gene, CHRNA4, is located.
conclusionsThe regions identified in the current study deserve close attention and will be helpful for candidate gene identification or target re-sequencing studies in the future.
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