ReviewTrends in cell biology2009
Shining new light on 3D cell motility and the metastatic process.
Review in Trends in cell biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- Analyzing cell migration history in vivo using fluorescent fibrillar collagen trails.Communications biology · 2026Article
- Melanoma Detection by AFM Indentation of Histological Specimens.Diagnostics (Basel, Switzerland) · 2022Article
- Multi-Cue Kinetic Model with Non-Local Sensing for Cell Migration on a Fiber Network with Chemotaxis.Bulletin of mathematical biology · 2022Article
- Mechanical Pressure Driving Proteoglycan Expression in Mammographic Density: a Self-perpetuating Cycle?Journal of mammary gland biology and neoplasia · 2021Review
- Navigating the Collagen Jungle: The Biomedical Potential of Fiber Organization in Cancer.Bioengineering (Basel, Switzerland) · 2021Review
- Fibrillar Collagen Quantification With Curvelet Transform Based Computational Methods.Frontiers in bioengineering and biotechnology · 2020Article
- Prolyl-4-hydroxylase Α subunit 2 (P4HA2) expression is a predictor of poor outcome in breast ductal carcinoma in situ (DCIS).British journal of cancer · 2018Article
- Bimodal sensing of guidance cues in mechanically distinct microenvironments.Nature communications · 2018Article
- Dynamics of 3D carcinoma cell invasion into aligned collagen.Integrative biology : quantitative biosciences from nano to macro · 2018Article
- Multiphoton fluorescence lifetime imaging of chemotherapy distribution in solid tumors.Journal of biomedical optics · 2017Article
- Anisotropic forces from spatially constrained focal adhesions mediate contact guidance directed cell migration.Nature communications · 2017Article
- Enhanced Directional Migration of Cancer Stem Cells in 3D Aligned Collagen Matrices.Biophysical journal · 2017Article
- Dual roles of CCN proteins in breast cancer progression.Journal of cell communication and signaling · 2016Article
- Multiscale Cues Drive Collective Cell Migration.Scientific reports · 2016Article
- Collective cell migration over long time scales reveals distinct phenotypes.Convergent science physical oncology · 2016Article
- Raised mammographic density: causative mechanisms and biological consequences.Breast cancer research : BCR · 2016Review
- Periductal stromal collagen topology of pancreatic ductal adenocarcinoma differs from that of normal and chronic pancreatitis.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2015Article
- Signaling networks that regulate cell migration.Cold Spring Harbor perspectives in biology · 2015Review
- The interaction between Shroom3 and Rho-kinase is required for neural tube morphogenesis in mice.Biology open · 2014Article
- Modeling persistence in mesenchymal cell motility using explicit fibers.Langmuir : the ACS journal of surfaces and colloids · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Understanding tissue architecture and physical and chemical reciprocity between cells and their microenvironment provides vital insights into key events in cancer metastasis, such as cell migration through three-dimensional (3D) extracellular matrices. Yet, many mechanistic details associated with metastasis remain elusive due to the difficulty of studying cancer cells in relevant 3D microenvironments. Recently, optical imaging has facilitated the direct observation of single cells as they undertake fundamental steps in the metastatic processes. Optical imaging is also providing novel 'optical biomarkers' with diagnostic potential that are linked to cell-motility pathways associated with metastasis, and these can to help guide new approaches to cancer diagnosis and therapy. Here we present recent advances in one subclass of optical imaging of particular promise for cellular imaging - multiphoton microscopy - that can be used to improve the detection of malignant cells as well as advance our understanding of the cell biology of cancer metastasis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.