ReviewBiochimica et biophysica acta2010
Carbonic anhydrase II-based metal ion sensing: Advances and new perspectives.
Review in Biochimica et biophysica acta, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
- Structure-function relationships in solvatochromic fluorophores targeting human and bovine carbonic anhydrases.Journal of inorganic biochemistry · 2025Article
- High-throughput assays to assess variant effects on disease.Disease models & mechanisms · 2024Article
- Pregnenolone derivatives for the treatment of Alzheimer's disease: synthesis, andRSC advances · 2024Article
- Purification, Characterization, cDNA Cloning, and Bioinformatic Analysis of Zinc-Binding Protein fromMolecules (Basel, Switzerland) · 2024Article
- Ratiometric Zinc Biosensor Based on Bioluminescence Resonance Energy Transfer: Trace Metal Ion Determination with Tunable Response.International journal of molecular sciences · 2022Article
- Emerging trends in environmental and industrial applications of marine carbonic anhydrase: a review.Bioprocess and biosystems engineering · 2022Review
- Arylphosphonate-Tethered Porphyrins: Fluorescence Silencing Speaks a Metal Language in Living Enterocytes*.Chembiochem : a European journal of chemical biology · 2021Article
- Combining Active Carbonic Anhydrase with Nanogels: Enzyme Protection and Zinc Sensing.International journal of nanomedicine · 2021Article
- Fluorescent Arylphosphonic Acids: Synergic Interactions between Bone and the Fluorescent Core.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- Mechanism of Action of Non-Synonymous Single Nucleotide Variations Associated withMolecules (Basel, Switzerland) · 2019Article
- Proximal renal tubular acidosis with and without Fanconi syndrome.Kidney research and clinical practice · 2019Review
- Renal Tubular Acidosis: HAdvances in chronic kidney disease · 2018Review
- Clinical Variants of New Delhi Metallo-β-Lactamase Are Evolving To Overcome Zinc Scarcity.ACS infectious diseases · 2017Article
- The biological inorganic chemistry of zinc ions.Archives of biochemistry and biophysics · 2016Article
- Techniques for measuring cellular zinc.Archives of biochemistry and biophysics · 2016Review
- Coordination contributions to protein stability in metal-substituted carbonic anhydrase.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2016Article
- Cadmium-containing carbonic anhydrase CDCA1 in marine diatom Thalassiosira weissflogii.Marine drugs · 2015Review
- Kinetics and thermodynamics of metal-binding to histone deacetylase 8.Protein science : a publication of the Protein Society · 2015Article
- Relationship between Zinc (Zn (2+) ) and Glutamate Receptors in the Processes Underlying Neurodegeneration.Neural plasticity · 2015Review
- Fluorescence lifetime imaging of physiological free Cu(II) levels in live cells with a Cu(II)-selective carbonic anhydrase-based biosensor.Metallomics : integrated biometal science · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Carbonic anhydrases are archetypical zinc metalloenzymes and as such, they have been developed as the recognition element of a family of fluorescent indicators (sensors) to detect metal ions, particularly Zn(2+) and Cu(2+). Subtle modification of the structure of human carbonic anhydrase II isozyme (CAII) alters the selectivity, sensitivity, and response time for these sensors. Sensors using CAII variants coupled with zinc-dependent fluorescent ligands demonstrate picomolar sensitivity, unmatched selectivity, ratiometric fluorescence signal, and near diffusion-controlled response times. Recently, these sensors have been applied to measuring the readily exchangeable concentrations of zinc in the cytosol and nucleus of mammalian tissue culture cells and concentrations of free Cu(2+) in seawater.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.