ArticleJournal of feline medicine and surgery2010
Mammary adenocarcinomas in three male cats exposed to medroxyprogesterone acetate (1990-2006).
Article in Journal of feline medicine and surgery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 34 citations in OpenAlex.
- Noninvasive malignant mammary adenomyoepithelioma in a male cat.Veterinary research communications · 2026Article
- Review
- Feline Mammary Tumors: A Comprehensive Review of Histological Classification Schemes, Grading Systems, and Prognostic Factors.Veterinary sciences · 2025Review
- Mammary carcinoma in a male cat following long-term medroxyprogesterone acetate treatment: case report and review of the literature.Veterinary research communications · 2024Review
- Epidemiologic and Clinicopathological Characterization of Feline Mammary Lesions.Veterinary sciences · 2024Article
- Evaluation of the efficacy and safety of toceranib phosphate in cats with macroscopic mammary adenocarcinoma.Journal of feline medicine and surgery · 2024Article
- Reversible control of reproduction in tom cats: medical options for manipulating libido and fertility.Journal of feline medicine and surgery · 2023Review
- Histologic evaluation of Ki-67 and cleaved caspase-3 expression in feline mammary carcinoma.Journal of feline medicine and surgery · 2017Article
- Mammary tumours in the cat: size matters, so early intervention saves lives.Journal of feline medicine and surgery · 2013Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this case series, three unrelated male housemate cats were treated repeatedly with injections of medroxyprogesterone acetate (MPA) for intercat aggression and urinary house soiling. All three cats subsequently developed multiple recurrent mammary adenocarcinomas and underwent numerous surgical resections. This report describes the clinical, histopathological and immunohistochemical findings in these three cats and highlights the potential for mammary carcinomas to develop in male cats years after receiving MPA injections. Extended survival times and a long delay between the administration of the progestin injections and the onset of mammary neoplasia are noted. Estrogen and progesterone receptor staining was performed on some of the tumors and the complex role of hormones in the pathogenesis and the prognosis of feline mammary carcinoma is discussed. Clinicians using MPA should institute life-long surveillance of their feline patients for mammary tumors.
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Registered trials
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