ArticleImmunity2009
Distinct conformations of Ly49 natural killer cell receptors mediate MHC class I recognition in trans and cis.
Article in Immunity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 61 citations in OpenAlex.
- Checkpoint Inhibition of KIR2D with the Monoclonal Antibody IPH2101 Induces Contraction and Hyporesponsiveness of NK Cells in Patients with Myeloma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2016Trial
- The challenge and promise of studying human antigen-specific T cells.Nature reviews. Immunology · 2026Review
- Antibody Blockade of Ly49/MHC-I interactions enhances Innate and Adaptive Immunity Against Cancer Metastasis.bioRxiv : the preprint server for biology · 2026Article
- Recognition of Self and Viral Ligands by NK Cell Receptors.Immunological reviews · 2025Review
- Structural and functional studies of the EGF20-27 region reveal new features of the human Notch receptor important for optimal activation.Structure (London, England : 1993) · 2024Article
- Homotypic and heterotypicCurrent research in immunology · 2022Review
- Topological and Structural Plasticity of the Single Ig Fold and the Double Ig Fold Present in CD19.Biomolecules · 2021Article
- Oligomeric Architecture of Mouse Activating Nkrp1 Receptors on Living Cells.International journal of molecular sciences · 2019Article
- NK cell education via nonclassical MHC and non-MHC ligands.Cellular & molecular immunology · 2017Review
- PirB regulates asymmetries in hippocampal circuitry.PloS one · 2017Article
- A pH- and ionic strength-dependent conformational change in the neck region regulates DNGR-1 function in dendritic cells.The EMBO journal · 2016Article
- Recognition of the Major Histocompatibility Complex (MHC) Class Ib Molecule H2-Q10 by the Natural Killer Cell Receptor Ly49C.The Journal of biological chemistry · 2016Article
- Cell-Extrinsic MHC Class I Molecule Engagement Augments Human NK Cell Education Programmed by Cell-Intrinsic MHC Class I.Immunity · 2016Article
- Slp-76 is a critical determinant of NK-cell mediated recognition of missing-self targets.European journal of immunology · 2015Article
- A positive cooperativity binding model between Ly49 natural killer cell receptors and the viral immunoevasin m157: kinetic and thermodynamic studies.The Journal of biological chemistry · 2014Article
- Complexity and Diversity of the NKR-P1:Clr (Klrb1:Clec2) Recognition Systems.Frontiers in immunology · 2014Review
- Structural basis for recognition of cellular and viral ligands by NK cell receptors.Frontiers in immunology · 2014Review
- Adaptations of Natural Killer Cells to Self-MHC Class I.Frontiers in immunology · 2014Article
- Structure of NKp65 bound to its keratinocyte ligand reveals basis for genetically linked recognition in natural killer gene complex.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Targeting of a natural killer cell receptor family by a viral immunoevasin.Nature immunology · 2013Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Certain cell-surface receptors engage ligands expressed on juxtaposed cells and ligands on the same cell. The structural basis for trans versus cis binding is not known. Here, we showed that Ly49 natural killer (NK) cell receptors bound two MHC class I (MHC-I) molecules in trans when the two ligand-binding domains were backfolded onto the long stalk region. In contrast, dissociation of the ligand-binding domains from the stalk and their reorientation relative to the NK cell membrane allowed monovalent binding of MHC-I in cis. The distinct conformations (backfolded and extended) define the structural basis for cis-trans binding by Ly49 receptors and explain the divergent functional consequences of cis versus trans interactions. Further analyses identified specific stalk segments that were not required for MHC-I binding in trans but were essential for inhibitory receptor function. These data identify multiple distinct roles of stalk regions for receptor function.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.