ReviewTrends in cell biology2009
Green light to illuminate signal transduction events.
Review in Trends in cell biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 27 citations in OpenAlex.
- The CaPediatric nephrology (Berlin, Germany) · 2025Review
- Lysophosphatidic Acid Receptor 3 (LPA3): Signaling and Phosphorylation Sites.International journal of molecular sciences · 2024Article
- Genetically encoded molecular probes to visualize and perturb signaling dynamics in living biological systems.Journal of cell science · 2014Review
- Imaging cell biology in live animals: ready for prime time.The Journal of cell biology · 2013Review
- The single T65S mutation generates brighter cyan fluorescent proteins with increased photostability and pH insensitivity.PloS one · 2012Article
- Genetically encodable fluorescent biosensors for tracking signaling dynamics in living cells.Chemical reviews · 2011Review
- KISS1R intracellular trafficking and degradation: effect of the Arg386Pro disease-associated mutation.Endocrinology · 2011Article
- Studying ligand efficacy at G protein-coupled receptors using FRET.Methods in molecular biology (Clifton, N.J.) · 2011Article
- Synthetic biology approaches in drug discovery and pharmaceutical biotechnology.Applied microbiology and biotechnology · 2010Review
- Putting G protein-coupled receptor-mediated activation of phospholipase C in the limelight.The Journal of general physiology · 2010Article
- Förster resonance energy transfer as a tool to study photoreceptor biology.Journal of biomedical opticsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
When cells are exposed to hormones that act on cell surface receptors, information is processed through the plasma membrane into the cell interior via second messengers generated in the inner leaflet of the plasma membrane. Individual biochemical steps along this cascade have been characterized from ligand binding to receptors through to activation of guanine nucleotide binding proteins and their downstream effectors such as adenylate cyclase or phospholipase C. However, the complexity of temporal and spatial integration of these molecular events requires that they are studied in intact cells. The great expansion of fluorescent techniques and improved imaging technologies such as confocal and TIRF microscopy combined with genetically-engineered protein modules has provided a completely new approach to signal transduction research. Spatial definition of biochemical events followed with real-time temporal resolution has become a standard goal, and several new techniques are now breaking the resolution barrier of light microscopy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.