ArticleAnnals of emergency medicine2010
A simple quantitative bedside test to determine methemoglobin.
Article in Annals of emergency medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Biomarkers in Snakebite: Will This be a Reality in Near Future?Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025Article
- Three cases of hemoglobin M disease in a family lineage: Case report and literature review.Medicine · 2025Review
- Case Report: Clinical presentations of cyanosis associated with acquired methemoglobinemia in infants-a clinical challenge.Frontiers in pediatrics · 2025Article
- A Rare Case of Familial Methemoglobinemia with Congenital Heart Disease.Oman medical journal · 2024Article
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- Article
- Alternative methods for calculating percentage haemolysis of red cell concentrates in peripheral blood banks in Sri Lanka.African journal of laboratory medicine · 2023Article
- METHEMOGLOBINEMIA - A CASE REPORT AND LITERATURE REVIEW.Acta clinica Croatica · 2022Review
- Clinical characteristics, treatment and outcomes of acute propanil poisoning in a 7-year retrospective cohort study.Toxicology reports · 2022Article
- Suspected Drinking Water Poisoning in a Domestic Kitten with Methemoglobinemia.Veterinary sciences · 2021Article
- Congenital methemoglobinemia: Rare presentation of cyanosis in newborns.Clinics and practice · 2019Article
- Article
- Methemoglobinemia: Living with Dormant Devil.Indian journal of clinical biochemistry : IJCB · 2017Article
- A bedside test for methemoglobinemia, Sri Lanka.Bulletin of the World Health Organization · 2016Article
- Two cases of methemoglobinemia: In a military community hospital.Canadian family physician Medecin de famille canadien · 2016Article
- Detecting Methemoglobinemia in Animals with a Drop of Blood.PloS one · 2016Article
- P-chloroaniline poisoning causing methemoglobinemia: a case report and review of the literature.Case reports in emergency medicine · 2015Article
- Diagnosis of snake envenomation using a simple phospholipase A2 assay.Scientific reports · 2014Article
- Method of stabilizing blood for the determination of methemoglobin.Journal of clinical laboratory analysis · 2011Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
STUDY
objectiveMethemoglobinemia after pesticide poisoning is associated with a mortality of 12% in Sri Lanka. Treatment is complicated by the lack of laboratory facilities. We aimed to develop and validate a low-cost bedside test for quantitative estimation of clinically significant methemoglobin to be used in settings of limited resources.
methodsA method to reliably produce blood samples with 10% to 100% methemoglobin was developed. Freshly prepared methemoglobin samples were used to develop the color chart. One drop (10 microL) of prepared methemoglobin sample was placed on white absorbent paper and scanned using a flatbed Cannon Scan LiDE 25 scanner. The mean red, green, and blue values were measured with ImageJ 1.37v. These color values were used to prepare a color chart to be used at the bedside. Interobserver agreement was assessed against prepared samples. The results from clinical use were compared with formal methemoglobin measurements.
resultsThe red color value was linearly related to percentage methemoglobin (R(2)=0.9938), with no effect of absolute hemoglobin concentration. Mean interobserver (N=21) agreement and weighted kappa for scanned methemoglobin spots using the color chart were 94% and 0.83, respectively. Mean interobserver (N=9) agreement and weighted kappa for a freshly prepared methemoglobin sample with the chart were 88% and 0.71, respectively. Clinical use of the color chart also showed good agreement with spectrometric measurements.
conclusionA color chart can be used to give a clinically useful quantitative estimate of methemoglobinemia.
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