ArticleDevelopmental biology2009
uninflatable encodes a novel ectodermal apical surface protein required for tracheal inflation in Drosophila.
Article in Developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 76 citations in OpenAlex.
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- Functional Analysis of a CTL-X-Type Lectin CTL16 in Development and Innate Immunity ofInternational journal of molecular sciences · 2023Article
- The Osiris family genes function as novel regulators of the tube maturation process in the Drosophila trachea.PLoS genetics · 2023Article
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- SVEP1 is a human coronary artery disease locus that promotes atherosclerosis.Science translational medicine · 2021Article
- GWAS reveal a role for the central nervous system in regulating weight and weight change in response to exercise.Scientific reports · 2021Article
- Glycosylhydrolase genes control respiratory tubes sizes and airway stability.Scientific reports · 2020Article
- The roles of jim lovell and uninflatable in different endopolyploid larval tissues of Drosophila melanogaster.PloS one · 2020Article
- Genome-wide Kdm4 histone demethylase transcriptional regulation in Drosophila.Molecular genetics and genomics : MGG · 2019Article
- QuBiT: a quantitative tool for analyzing epithelial tubes reveals unexpected patterns of organization in theDevelopment (Cambridge, England) · 2019Article
- WASH phosphorylation balances endosomal versus cortical actin network integrities during epithelial morphogenesis.Nature communications · 2019Article
- The Caspase-3 homolog DrICE regulates endocytic trafficking during Drosophila tracheal morphogenesis.Nature communications · 2019Article
- Conserved function of the matriptase-prostasin proteolytic cascade during epithelial morphogenesis.PLoS genetics · 2019Article
- The apical protein Apnoia interacts with Crumbs to regulate tracheal growth and inflation.PLoS genetics · 2019Article
- Article
- Development and Function of theGenetics · 2018Review
- A Burrowing/Tunneling Assay for Detection of Hypoxia in Drosophila melanogaster Larvae.Journal of visualized experiments : JoVE · 2018Article
- Adult functions for the Drosophila DHR78 nuclear receptor.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
The tracheal system of Drosophila melanogaster has proven to be an excellent model system for studying the development of branched tubular organs. Mechanisms regulating the patterning and initial maturation of the tracheal system have been largely worked out, yet important questions remain regarding how the mature tubes inflate with air at the end of embryogenesis, and how the tracheal system grows in response to the oxygen needs of a developing larva that increases nearly 1000-fold in volume over a four day period. Here we describe the cloning and characterization of uninflatable (uif), a gene that encodes a large transmembrane protein containing carbohydrate binding and cell signaling motifs in its extracellular domain. Uif is highly conserved in insect species, but does not appear to have a true ortholog in vertebrate species. uif is expressed zygotically beginning in stage 5 embryos, and Uif protein localizes to the apical plasma membrane in all ectodermally derived epithelia, most notably in the tracheal system. uif mutant animals show defects in tracheal inflation at the end of embryogenesis, and die primarily as larvae. Tracheal tubes in mutant larvae are often crushed or twisted, although tracheal patterning and maturation appear normal during embryogenesis. uif mutant larvae also show defects in tracheal growth and molting of their tracheal cuticle.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.