ArticleGenes, brain, and behavior2010
Serotonin transporter expression is predicted by early life stress and is associated with disinhibited behavior in infant rhesus macaques.
Article in Genes, brain, and behavior, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 123 citations in OpenAlex.
- Parenting and the Serotonin Transporter Gene (5HTTLPR), Is There an Association? A Systematic Review of the Literature.International journal of environmental research and public health · 2022Pooled it
- Stress in the social context: a behavioural and eco-evolutionary perspective.The Journal of experimental biology · 2023Review
- Early life adversity shapes neural circuit function during sensitive postnatal developmental periods.Translational psychiatry · 2022Review
- Behavioral mimicry predicts social favor in adolescent rhesus macaques (Macaca mulatta).Primates; journal of primatology · 2021Article
- Serotonin Transporter Binding Potentials in Brain of Juvenile Monkeys 1 Year After Discontinuation of a 2-Year Treatment With Fluoxetine.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Article
- Early-life stress origins of gastrointestinal disease: animal models, intestinal pathophysiology, and translational implications.American journal of physiology. Gastrointestinal and liver physiology · 2015Review
- Increased aggressive and affiliative display behavior in intrauterine growth restricted baboons.Journal of medical primatology · 2015Article
- Epigenetic alterations following early postnatal stress: a review on novel aetiological mechanisms of common psychiatric disorders.Clinical epigenetics · 2015Review
- Gene-environment interaction in major depression: focus on experience-dependent biological systems.Frontiers in psychiatry · 2015Review
- Influence of life stress, 5-HTTLPR genotype, and SLC6A4 methylation on gene expression and stress response in healthy Caucasian males.Biology of mood & anxiety disorders · 2015Article
- Serotonin transporter [corrected] methylation and response to cognitive behaviour therapy in children with anxiety disorders.Translational psychiatry · 2014Article
- Effects of genetic and early environmental risk factors for depression on serotonin transporter expression and methylation profiles.Translational psychiatry · 2014Article
- Article
- Social environmental effects on gene regulation.Cellular and molecular life sciences : CMLS · 2013Review
- Increased serotonin transporter gene (SERT) DNA methylation is associated with bullying victimization and blunted cortisol response to stress in childhood: a longitudinal study of discordant monozygotic twins.Psychological medicine · 2013Article
- Inflammatory vulnerability associated with the rh5-HTTLPR genotype in juvenile rhesus monkeys.Genes, brain, and behavior · 2013Article
- Peripuberty stress leads to abnormal aggression, altered amygdala and orbitofrontal reactivity and increased prefrontal MAOA gene expression.Translational psychiatry · 2013Article
- Article
- Acupuncture stimulation at HT7 alleviates depression-induced behavioral changes via regulation of the serotonin system in the prefrontal cortex of maternally-separated rat pups.The journal of physiological sciences : JPS · 2012Article
- Genetic determinants of aggression and impulsivity in humans.Journal of applied genetics · 2012Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Serotonin transporter (5-HTT) expression patterns may contribute to the risk for adverse psychological outcomes following early life stress. The present study investigated whether two types of early life stress, maternal and social aggression, and a serotonin transporter gene promoter polymorphism (rh5-HTTLPR) predicted lower post-stressor peripheral blood mononuclear cell (PBMC) 5-HTT expression in infant rhesus macaques. We further probed the relationships among these factors and infant behavioral disinhibition within a stressful situation. Fifty-three infants residing with mothers in large, complex social groups were observed over the first 12 postnatal weeks, during which time the rate of aggression received by the infant from their mothers and social group members was recorded. At 90-120 days of age, infants underwent a 25-h maternal separation/biobehavioral assessment, which included standardized behavioral assessments and blood sampling. Infants' rh5-HTTLPR genotypes were determined, and infant 5-HTT expression was quantified from PBMCs collected 8 h after separation. Receipt of aggression from the mother, but not from social group members, was associated with lower post-stressor 5-HTT expression. Lower post-stressor 5-HTT expression, but not receipt of aggression, was associated with disinhibited behavior during assessment. Rh5-HTTLPR genotype was unrelated to any measure. We conclude that 5-HTT regulation is linked with specific, presumably stressful early experiences in infant rhesus macaques. Further, 5-HTT expression predicted behavioral disinhibition, presumably via parallel processes that operate in the brain.
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