ArticleThe European journal of neuroscience2009
Pairing mild stress with increased serotonin-1B receptor expression in the nucleus accumbens increases susceptibility to amphetamine.
Article in The European journal of neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Stress decreases serotonin tone in the nucleus accumbens in male mice to promote aversion and potentiate cocaine preference via decreased stimulation of 5-HTNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Effects of a 5-HTFrontiers in systems neuroscience · 2017Article
- 5-HT1B autoreceptors differentially modulate the expression of conditioned fear in a circuit-specific manner.Neuroscience · 2015Article
- Reductions in brain 5-HT1B receptor availability in primarily cocaine-dependent humans.Biological psychiatry · 2014Article
- Differential effect of viral overexpression of nucleus accumbens shell 5-HT1B receptors on stress- and cocaine priming-induced reinstatement of cocaine seeking.Pharmacology, biochemistry, and behavior · 2013Article
- Brief daily postpartum separations from the litter alter dam response to psychostimulants and to stress.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2013Article
- Serotonin 1B receptor imaging in pathological gambling.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2013Article
- Differential distribution of serotonin receptor subtypes in BNST(ALG) neurons: modulation by unpredictable shock stress.Neuroscience · 2012Article
- Virogenetic and optogenetic mechanisms to define potential therapeutic targets in psychiatric disorders.Neuropharmacology · 2012Review
- 5-HT1B mRNA expression after chronic social stress.Behavioural brain research · 2011Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Both serotonin-1B (5-HT(1B)) receptors and stress modulate the behavioral and neurobiological effects of psychostimulant drugs. In order to examine how these factors interact to influence the development of behaviors associated with addiction, we used viral-mediated gene transfer to transiently increase expression of 5-HT(1B) receptors in the nucleus accumbens (NAc) shell along with exposure to repeated mild stress (novelty + saline injection) in rats. Once the viral-mediated increases in gene expression had dissipated, the resulting effects of this 5-HT(1B)/stress pairing on the acute locomotor response to amphetamine and on the development of psychomotor sensitization were examined. We report that the increasing expression of 5-HT(1B) receptors on the terminals of NAc shell neurons that project to the ventral tegmental area and repeatedly exposing rats to mild stress subsequently enhance the acute locomotor-activating effects of amphetamine. In addition, the development of psychomotor sensitization (both locomotor activity and stereotypy components) is facilitated. These results suggest that serotonin signaling through NAc 5-HT(1B) heteroreceptors can interact with stress to increase susceptibility to the enduring forms of drug-induced plasticity that are associated with addiction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.