ArticleExpert review of molecular diagnostics2009
Emergence of single-molecule sequencing and potential for molecular diagnostic applications.
Article in Expert review of molecular diagnostics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- A Critical Review on the Sensing, Control, and Manipulation of Single Molecules on Optofluidic Devices.Micromachines · 2022Review
- Recent advances in integrated solid-state nanopore sensors.Lab on a chip · 2021Review
- Cell Separations and Sorting.Analytical chemistry · 2020Review
- Single molecule targeted sequencing for cancer gene mutation detection.Scientific reports · 2016Article
- Improving pancreatic cancer diagnosis using circulating tumor cells: prospects for staging and single-cell analysis.Expert review of molecular diagnostics · 2015Review
- Amelogenesis imperfecta and screening of mutation in amelogenin gene.Case reports in dentistry · 2014Article
- Next-generation sequencing in the clinic: promises and challenges.Cancer letters · 2013Review
- DNA sequencing and bar-coding using solid-state nanopores.Electrophoresis · 2012Review
- Single-step capture and sequencing of natural DNA for detection of BRCA1 mutations.Genome research · 2012Article
- Survival bias and drug interaction can attenuate cross-sectional case-control comparisons of genes with health outcomes. An example of the kinesin-like protein 6 (KIF6) Trp719Arg polymorphism and coronary heart disease.BMC medical genetics · 2011Article
- Microfluidic-based biosensors toward point-of-care detection of nucleic acids and proteins.Microfluidics and nanofluidics · 2011Review
- The properties and applications of single-molecule DNA sequencing.Genome biology · 2011Review
- Next generation sequencing for clinical diagnostics-principles and application to targeted resequencing for hypertrophic cardiomyopathy: a paper from the 2009 William Beaumont Hospital Symposium on Molecular Pathology.The Journal of molecular diagnostics : JMD · 2010Review
- Enhanced Single-Molecule Detection using Porous Silver Membrane.The journal of physical chemistry. C, Nanomaterials and interfaces · 2010Article
- [The next generation sequencing technology and its application in cancer research].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The effective demonstration of single-molecule sequencing at scale over the last several years offers the exciting opportunity for a new era in the field of molecular diagnostics. As we aim to personalize and deliver cost-effective healthcare, we must consider the need to fully integrate genomics into decision-making. We must be able to accurately and cost effectively obtain a complete genome sequence for disease diagnosis, interrogate a molecular signature from blood for therapeutic monitoring, obtain a tumor mutation profile for optimizing therapeutic choice - each molecular diagnostic measurement utilized to better inform patient care. Would a physician or molecular pathology laboratory want to utilize a PCR process in which millions of DNA copies of a patient's nucleic acid are created when an alternative approach allowing direct measurement of the nucleic acids is possible? I would suggest not! In this article we will focus on the emergence of single-molecule sequencing, the single-molecule sequencing methodologies in the marketplace or under development today, as well as the importance of these methods for molecular characterization and diagnosis of disease with the ultimate application for molecular diagnostics.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.