ArticleJournal of the American Chemical Society2009
Oxazine conjugated nanoparticle detects in vivo hypochlorous acid and peroxynitrite generation.
Article in Journal of the American Chemical Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 178 citations in OpenAlex.
- A Coumarin Derived 2-Methylthio-4-Hydroxypyrimidine[3,4-b]coumarin Fluorescent Chemosensor for Detection of Hypochlorite Ions in Aqueous Medium.Journal of fluorescence · 2026Article
- Double-layer optical fiber interferometer with bio-layer-modified reflector for label-free biosensing of inflammatory proteins.Scientific reports · 2024Article
- Accurate imaging in the processes of formation and inhibition of drug-induced liver injury by an activable fluorescent probe for ONOOMaterials today. Bio · 2023Article
- Research Progress of Neutrophil-Mediated Drug Delivery Strategies for Inflammation-Related Disease.Pharmaceutics · 2023Review
- New Application of the Commercially Available Dye Celestine Blue B as a Sensitive and Selective Fluorescent "Turn-On" Probe for Endogenous Detection of HOCl and Reactive Halogenated Species.Antioxidants (Basel, Switzerland) · 2022Article
- A model of metformin mitochondrial metabolism in metachromatic leukodystrophy: first description of human Schwann cells transfected with CRISPR-Cas9.Open biology · 2022Article
- Fluorescent Biosensors Based on Silicon Nanowires.Nanomaterials (Basel, Switzerland) · 2021Review
- Different Approaches to Develop Nanosensors for Diagnosis of Diseases.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Review
- An activatable PET imaging radioprobe is a dynamic reporter of myeloperoxidase activity in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- A versatile imaging platform with fluorescence and CT imaging capabilities that detects myeloperoxidase activity and inflammation at different scales.Theranostics · 2019Article
- Redox Signaling by Reactive Electrophiles and Oxidants.Chemical reviews · 2018Review
- Rapid Response Fluorescence Probe Enabled In Vivo Diagnosis and Assessing Treatment Response of Hypochlorous Acid-Mediated Rheumatoid Arthritis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2018Article
- Ratiometric Reactive Oxygen Species Nanoprobe for Noninvasive In Vivo Imaging of Subcutaneous Inflammation/Infection.Journal of biomedical nanotechnology · 2016Article
- Mechanism of oxidative conversion of Amplex® Red to resorufin: Pulse radiolysis and enzymatic studies.Free radical biology & medicine · 2016Article
- Methods for measuring myeloperoxidase activity toward assessing inhibitor efficacy in living systems.Journal of leukocyte biology · 2016Review
- Protonation and Trapping of a Small pH-Sensitive Near-Infrared Fluorescent Molecule in the Acidic Tumor Environment Delineate Diverse Tumors in Vivo.Molecular pharmaceutics · 2015Article
- Nanoimaging in cardiovascular diseases: Current state of the art.The Indian journal of medical research · 2015Review
- Core-shell structured phosphorescent nanoparticles for detection of exogenous and endogenous hypochlorite in live cellsChemical science · 2015Article
- Molecular imaging of bacterial infections in vivo: the discrimination of infection from inflammation.Informatics (MDPI) · 2014Article
- Bioabsorbable stent quo vadis: a case for nano-theranostics.Theranostics · 2014Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
The current lack of suitable probes has limited the in vivo imaging of reactive oxygen/nitrogen species (ROS/RNS). ROS/RNS are often generated by ischemia-induced inflammation; defining the extent of tissue involvement or ROS/RNS-related damage would have a significant clinical impact. We present the preparation and demonstration of a fluorogenic sensor for monitoring peroxynitrite (ONOO(-)) and myeloperoxidase (MPO) mediated hypochlorous acid (HOCl/OCl(-)) production. The sensor consists of a long circulating biocompatible nanoparticle that targets phagocytic cells in vivo and is coated with approximately 400 quenched oxazine fluorophores that are released by reaction with HOCl or ONOO(-) but are stable toward oxidants such as hydroxyl radical, hydrogen peroxide, and superoxide. MPO-dependent probe activation is chloride ion dependent and is negated in flow cytometry studies of MPO inhibitor treated neutrophils. Fluorescence reflectance imaging and microscopic fluorescence imaging in mouse hearts after myocardial infarction showed probe release into neutrophil-rich ischemic areas, making this ROS/RNS sensor a novel prognostic indicator.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.