ArticleJournal of medicinal chemistry2009
Phenoxy herbicides and fibrates potently inhibit the human chemosensory receptor subunit T1R3.
Article in Journal of medicinal chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- Clofibrate inhibits the umami-savory taste of glutamate.PloS one · 2017Trial
- Distinct potency of compounds targeting the T1R3 subunit in modulating the response of human sweet and umami taste receptors.Scientific reports · 2025Article
- Ibuprofen inhibits human sweet taste and glucose detection implicating an additional mechanism of metabolic disease risk reduction.British journal of pharmacology · 2025Article
- Prediction of dynamic allostery for the transmembrane domain of the sweet taste receptor subunit, TAS1R3.Communications biology · 2023Article
- Pharmacology of the Umami Taste Receptor.Handbook of experimental pharmacology · 2022Article
- Recent progress in the use of diaziridine-based sweetener derivatives to elucidate the chemoreception mechanism of the sweet taste receptor.RSC advances · 2021Review
- Fenofibrate and Impaired Taste Perception in Type 2 Diabetes.The American journal of case reports · 2020Article
- Asymmetric Synthesis of Photophore-Containing Lactisole Derivatives to Elucidate Sweet Taste Receptors.Molecules (Basel, Switzerland) · 2020Article
- G Protein-Coupled Receptors in Taste Physiology and Pharmacology.Frontiers in pharmacology · 2020Review
- Taste Receptors: New Players in Sperm Biology.International journal of molecular sciences · 2019Review
- Structural insights into the differences among lactisole derivatives in inhibitory mechanisms against the human sweet taste receptor.PloS one · 2019Article
- Lipid-Lowering Pharmaceutical Clofibrate Inhibits Human Sweet Taste.Chemical senses · 2017Article
- Extraoral Taste Receptor Discovery: New Light on Ayurvedic Pharmacology.Evidence-based complementary and alternative medicine : eCAM · 2017Review
- Dual mechanism for bitter avoidance in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Minireview: Nutrient sensing by G protein-coupled receptors.Molecular endocrinology (Baltimore, Md.) · 2013Review
- Genetic loss or pharmacological blockade of testes-expressed taste genes causes male sterility.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The G protein-coupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy.Molecular cell · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
We show that phenoxyauxin herbicides and lipid-lowering fibrates inhibit human but not rodent T1R3. T1R3 as a coreceptor in taste cells responds to sweet compounds and amino acids; in endocrine cells of gut and pancreas T1R3 contributes to glucose sensing. Thus, certain effects of fibrates in treating hyperlipidemia and type II diabetes may be via actions on T1R3. Likewise, phenoxy herbicides may have adverse metabolic effects in humans that would have gone undetected in studies on rodents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.