ArticleStem cells (Dayton, Ohio)2009
Self-renewal of the long-term reconstituting subset of hematopoietic stem cells is regulated by Ikaros.
Article in Stem cells (Dayton, Ohio), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- IKAROS deletions dictate a unique gene expression signature in patients with adult B-cell acute lymphoblastic leukemia.PloS one · 2012Trial
- Single-cell map of the healthy human immune system across the lifespan reveals unique infant immune signatures.Nature communications · 2026Article
- Interleukin-12 Supports Self-renewal Division of Mouse Hematopoietic Stem Cells in Polyvinyl Alcohol-Based Culture.Stem cell reviews and reports · 2026Article
- IKAROS and AIOLOS directly regulate AP-1 transcriptional complexes and are essential for NK cell development.Nature immunology · 2024Article
- IKAROS Family Transcription Factors in Lymphocyte Differentiation and Function.Advances in experimental medicine and biology · 2024Review
- Ikzf1 regulates embryonic T lymphopoiesis via Ccr9 and Irf4 in zebrafish.The Journal of biological chemistry · 2019Article
- IKZF2 Drives Leukemia Stem Cell Self-Renewal and Inhibits Myeloid Differentiation.Cell stem cell · 2019Article
- Impact of the c-MybE308G mutation on mouse myelopoiesis and dendritic cell development.PloS one · 2017Article
- miR-221 attenuates the osteogenic differentiation of human annulus fibrosus cells.The spine journal : official journal of the North American Spine Society · 2016Article
- Article
- The IKAROS interaction with a complex including chromatin remodeling and transcription elongation activities is required for hematopoiesis.PLoS genetics · 2014Article
- A dominant-negative isoform of IKAROS expands primitive normal human hematopoietic cells.Stem cell reports · 2014Article
- Hematopoiesis in steady-state versus stress: self-renewal, lineage fate choice, and the conversion of danger signals into cytokine signals in hematopoietic stem cells.Journal of immunology (Baltimore, Md. : 1950) · 2014Review
- Ikaros transcripts Ik6/10 and levels of full-length transcript are critical for chronic myeloid leukaemia blast crisis transformation.Leukemia · 2014Article
- Epstein-Barr virus utilizes Ikaros in regulating its latent-lytic switch in B cells.Journal of virology · 2014Article
- Characterisation of dendritic cells arising from progenitors endogenous to murine spleen.PloS one · 2014Article
- ARID5B and IKZF1 variants, selected demographic factors, and childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group.Leukemia research · 2013Article
- Long and short non-coding RNAs as regulators of hematopoietic differentiation.International journal of molecular sciences · 2013Review
- Challenging the axiom: does the occurrence of oncogenic mutations truly limit cancer development with age?Oncogene · 2013Review
- Ikaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signaling.Blood · 2013Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
Hematopoietic stem cells (HSCs) are rare, ancestral cells that underlie the development, homeostasis, aging, and regeneration of the blood. Here we show that the chromatin-associated protein Ikaros is a crucial self-renewal regulator of the long-term (LT) reconstituting subset of HSCs. Ikaros, and associated family member proteins, are highly expressed in self-renewing populations of stem cells. Ikaros point mutant mice initially develop LT-HSCs with the surface phenotype cKit+Thy1.1(lo)Lin(-/lo)Sca1+Flk2-CD150+ during fetal ontogeny but are unable to maintain this pool, rapidly losing it within two days of embryonic development. A synchronous loss of megakaryocyte/erythrocyte progenitors results, along with a fatal, fetal anemia. At this time, mutation of Ikaros exerts a differentiation defect upon common lymphoid progenitors that cannot be rescued with an ectopic Notch signal in vitro, with hematopoietic cells preferentially committing to the NK lineage. Althoughdispensable for the initial embryonic development of blood, Ikaros is clearly needed for maintenance of this tissue. Achieving successful clinical tissue regeneration necessitates understanding degeneration, and these data provide a striking example by a discrete genetic lesion in the cells underpinning tissue integrity during a pivotal timeframe of organogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.