ArticleNature protocols2009
Housing conditions and stimulus females: a robust social discrimination task for studying male rodent social recognition.
Article in Nature protocols, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 46 citations in OpenAlex.
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- Medial PFC AMPA receptor and BDNF signaling are required for the rapid and sustained antidepressant-like effects of 5-HTNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- GABA interneurons are the cellular trigger for ketamine's rapid antidepressant actions.The Journal of clinical investigation · 2020Article
- Autistic traits in epilepsy models: Why, when and how?Epilepsy research · 2018Review
- Behavioral and neuroanatomical approaches in models of neurodevelopmental disorders: opportunities for translation.Current opinion in neurology · 2018Review
- Modulation of neuroinflammation and pathology in the 5XFAD mouse model of Alzheimer's disease using a biased and selective beta-1 adrenergic receptor partial agonist.Neuropharmacology · 2017Article
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- High-Fat Diet Induced Anxiety and Anhedonia: Impact on Brain Homeostasis and Inflammation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Neural Androgen Receptors Modulate Gene Expression and Social Recognition But Not Social Investigation.Frontiers in behavioral neuroscience · 2016Article
- The SocioBox: A Novel Paradigm to Assess Complex Social Recognition in Male Mice.Frontiers in behavioral neuroscience · 2016Article
- Effects of sex and gonadectomy on social investigation and social recognition in mice.BMC neuroscience · 2015Article
- Lesions to the CA2 region of the hippocampus impair social memory in mice.The European journal of neuroscience · 2014Article
- Effect of combining anesthetics in neonates on long-term cognitive function.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2014Article
- β1-adrenergic receptor activation enhances memory in Alzheimer's disease model.Annals of clinical and translational neurology · 2014Article
- Early exposure to volatile anesthetics impairs long-term associative learning and recognition memory.PloS one · 2014Article
- Social recognition is context dependent in single male prairie voles.Animal behaviour · 2013Article
- Article
- Evidence for sustained elevation of IL-6 in the CNS as a key contributor of depressive-like phenotypes.Translational psychiatry · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Social recognition (SR) enables rodents to distinguish between familiar and novel conspecifics, largely through individual odor cues. SR tasks utilize the tendency for a male to sniff and interact with a novel individual more than a familiar individual. Many paradigms have been used to study the roles of the neuropeptides oxytocin and vasopressin in SR. However, inconsistencies in results have arisen within similar mouse strains, and across different paradigms and laboratories, making reliable testing of SR difficult. The current protocol details a novel approach that is replicable across investigators and in different strains of mice. We created a protocol that uses gonadally intact, singly housed females presented within corrals to group-housed males. Housing females singly before testing is particularly important for reliable discrimination. This methodology will be useful for studying short-term social memory in rodents, and may also be applicable for longer term studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.