ArticleThe EMBO journal2009
TOC1 functions as a molecular switch connecting the circadian clock with plant responses to drought.
Article in The EMBO journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 162 papers.
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162 citing papers in PubMed, 362 citations in OpenAlex.
- Differential Responses inPlants (Basel, Switzerland) · 2026Article
- Time after time: a quarter century of progress in plant circadian biology.Npj biological timing and sleep · 2026Review
- TOC1 phosphorylation disproportionally enhances chromatin binding at rhythmic gene promoters.Science advances · 2025Article
- Transcriptional activation and repression in the plant circadian clock: Revisiting core oscillator feedback loops and output pathways.Plant communications · 2025Review
- Metabolism in Sync: The Circadian Clock, a Central Hub for Light-Driven Chloroplastic and Mitochondrial Entrainment.Plants (Basel, Switzerland) · 2025Review
- The core morning clock component CCA1 enhances UPR target gene expression to facilitate ER stress recovery.Plant communications · 2025Article
- A telomere-to-telomere gapless genome reveals SlPRR1 control of circadian rhythm and photoperiodic flowering in tomato.GigaScience · 2025Article
- Article
- The overexpression of the switchgrass (Panicum virgatum L.) genes PvTOC1-N or PvLHY-K affects circadian rhythm and hormone metabolism in transgenic Arabidopsis seedlings.Biotechnology for biofuels and bioproducts · 2024Article
- Integrated Metabolome and Transcriptome Analysis of Gibberellins Mediated the Circadian Rhythm of Leaf Elongation by Regulating Lignin Synthesis in Maize.International journal of molecular sciences · 2024Article
- Unlocking allelic variation in circadian clock genes to develop environmentally robust and productive crops.Planta · 2024Review
- The interplay between the circadian clock and abiotic stress responses mediated by ABF3 and CCA1/LHY.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A Multi-Omics Analysis Revealed the Diversity of the MYB Transcription Factor Family's Evolution and Drought Resistance Pathways.Life (Basel, Switzerland) · 2024Article
- Effects of Exogenous Abscisic Acid on the Physiological and Biochemical Responses ofPlants (Basel, Switzerland) · 2024Article
- The Roles of Circadian Clock Genes in Plant Temperature Stress Responses.International journal of molecular sciences · 2024Review
- Investigating Circadian Gating of Temperature Responsive Genes.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Environmental F actors coordinate circadian clock function and rhythm to regulate plant development.Plant signaling & behavior · 2023Review
- The Roles of theInternational journal of molecular sciences · 2023Article
- Acclimation of circadian rhythms in woodland strawberries (Fragaria vesca L.) to Arctic and mid-latitude photoperiods.BMC plant biology · 2023Article
- Inhibition of RNA degradation integrates the metabolic signals induced by osmotic stress into the Arabidopsis circadian system.Journal of experimental botany · 2023Article
102 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite our increasing knowledge on the transcriptional networks connecting abscisic acid (ABA) signalling with the circadian clock, the molecular nodes in which both pathways converge to translate the environmental information into a physiological response are not known. Here, we provide evidence of a feedback mechanism linking the circadian clock with plant responses to drought. A key clock component (TOC1, timing of CAB expression 1) binds to the promoter of the ABA-related gene (ABAR/CHLH/GUN5) and controls its circadian expression. TOC1 is in turn acutely induced by ABA and this induction advances the phase of TOC1 binding and modulates ABAR circadian expression. Moreover, the gated induction of TOC1 by ABA is abolished in ABAR RNAi plants suggesting that the reciprocal regulation between ABAR and TOC1 expression is important for sensitized ABA activity. Genetic studies with TOC1 and ABAR over-expressing and RNAi plants showed defective responses to drought, which support the notion that clock-dependent gating of ABA function is important for cellular homeostasis under dry environments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.