ArticleCirculation research2009
Progenitor cells from the explanted heart generate immunocompatible myocardium within the transplanted donor heart.
Article in Circulation research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Far-Infrared Therapy Decreases Orthotopic Allograft Transplantation Vasculopathy.Biomedicines · 2022Article
- Dipeptidyl Peptidase-4 Inhibitor Decreases Allograft Vasculopathy Via Regulating the Functions of Endothelial Progenitor Cells in Normoglycemic Rats.Cardiovascular drugs and therapy · 2021Article
- Transferring Plasmon Effect on a Biological System: Expression of Biological Polymers in Chronic Rejection and Inflammatory Rat Model.Polymers · 2021Article
- Cardiac allograft vasculopathy: a donor or recipient induced pathology?Journal of cardiovascular translational research · 2015Review
- Differentiation induction of mouse cardiac stem cells into sinus node-like cells by co-culturing with sinus node.International journal of clinical and experimental pathology · 2014Article
- Surgical options for the management of ischemic cardiomyopathy.Current treatment options in cardiovascular medicine · 2013Article
- Cardiomyogenesis in the developing heart is regulated by c-kit-positive cardiac stem cells.Circulation research · 2012Article
- Article
- Effects of age and heart failure on human cardiac stem cell function.The American journal of pathology · 2011Article
- Adult mouse epicardium modulates myocardial injury by secreting paracrine factors.The Journal of clinical investigation · 2011Article
- Stem cell update: highlights from the 2010 Lugano Stem Cell Meeting.Journal of cardiovascular translational research · 2011Article
- Article
- Article
- Current and future status of stem cell therapy in heart failure.Current treatment options in cardiovascular medicine · 2010Article
- Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiation.Circulation research · 2010Article
- Stem cell therapy for heart failure.Methodist DeBakey cardiovascular journalReview
Corrections and comments
- Retraction · 2018-12-12Concerns/Issues about Data · Investigation by Company/Institution · Misconduct - Official Investigation(s) and/or Finding(s) · Upgrade/Update of Prior Notice(s) · · Carlos Rondon-Clavo aka Carlos Clavo-Rondon;
- Expression of concern · 2018-11-20Concerns/Issues about Data · Investigation by Company/Institution · Misconduct - Official Investigation(s) and/or Finding(s) · Updated to Retraction · · Carlos Rondon-Clavo aka Carlos Clavo-Rondon;
- Expression of concern
- Expression of concern
- Retracted
Authors and funding
19 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleChronic rejection, accelerated coronary atherosclerosis, myocardial infarction, and ischemic heart failure determine the unfavorable evolution of the transplanted heart in humans.
objectiveHere we tested whether the pathological manifestations of the transplanted heart can be corrected partly by a strategy that implements the use of cardiac progenitor cells from the recipient to repopulate the donor heart with immunocompatible cardiomyocytes and coronary vessels. METHODS AND
resultsA large number of cardiomyocytes and coronary vessels were created in a rather short period of time from the delivery, engraftment, and differentiation of cardiac progenitor cells from the recipient. A proportion of newly formed cardiomyocytes acquired adult characteristics and was integrated structurally and functionally within the transplant. Similarly, the regenerated arteries, arterioles, and capillaries were operative and contributed to the oxygenation of the chimeric myocardium. Attenuation in the extent of acute damage by repopulating cardiomyocytes and vessels decreased significantly the magnitude of myocardial scarring preserving partly the integrity of the donor heart.
conclusionsOur data suggest that tissue regeneration by differentiation of recipient cardiac progenitor cells restored a significant portion of the rejected donor myocardium. Ultimately, immunosuppressive therapy may be only partially required improving quality of life and lifespan of patients with cardiac transplantation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.