ArticleJournal of applied physiology (Bethesda, Md. : 1985)2009
Effect of whole body heat stress on peripheral vasoconstriction during leg dependency.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Meta-analysis of heat-induced changes in cardiac function from over 400 laboratory-based heat exposure studies.Nature communications · 2025Pooled it
- Sweat loss during heat stress contributes to subsequent reductions in lower-body negative pressure tolerance.Experimental physiology · 2013Trial
- Colloid volume loading does not mitigate decreases in central blood volume during simulated haemorrhage while heat stressed.The Journal of physiology · 2012Trial
- Cell-free DNA, cytokine, and catecholamine levels did not differ between sexes under a matched body core temperature increase, despite females exhibiting a more rapid increase in rectal temperature.European journal of applied physiology · 2026Article
- Ageing attenuates regional vasoconstriction during acute lowering of upper and lower limbs.Experimental physiology · 2026Article
- In vivo pressure-flow relation of human cutaneous vessels following prolonged iterative exposures to hypergravity.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Effect of reflex and mechanical decreases in skin perfusion on thermal- and agonist-induced eccrine sweating in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Variability of peripheral pulse wave velocity in patients with diabetes mellitus type 2 during orthostatic challenge.Physiological research · 2020Article
- Prolonged standing increases lower limb arterial stiffness.European journal of applied physiology · 2018Article
- Measuring and quantifying skin sympathetic nervous system activity in humans.Journal of neurophysiology · 2017Review
- Mechanisms of orthostatic intolerance during heat stress.Autonomic neuroscience : basic & clinical · 2016Review
- Repeated core temperature elevation induces conduit artery adaptation in humans.European journal of applied physiology · 2014Article
- Human skeletal muscle feed arteries studied in vitro: the effect of temperature on α(1)-adrenergic responsiveness.Experimental physiology · 2011Article
- Combined heat and mental stress alters neurovascular control in humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Article
- Obligatory role of hyperaemia and shear stress in microvascular adaptation to repeated heating in humans.The Journal of physiology · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The venoarteriolar response (VAR) increases vascular resistance upon increases in venous transmural pressure in cutaneous, subcutaneous, and muscle vascular beds. During orthostasis, it has been proposed that up to 45% of the increase in systemic vascular tone is due to VAR-related local mechanism(s). The objective of this project was to test the hypothesis that heat stress attenuates VAR-mediated cutaneous and whole leg vasoconstriction. During normothermic conditions, measurements of cutaneous blood flow (laser-Doppler flowmetry) and femoral artery blood flow (Doppler ultrasound) were obtained from both legs during supine and leg-dependent conditions. These measurements were repeated following a whole body heat stress (increase in internal temperature of 1.4 +/- 0.2 degrees C). Before leg dependency, cutaneous (CVC) and femoral vascular conductances (FVC) were significantly elevated in both legs during heat stress relative to normothermia (P < 0.001). During leg dependency the absolute decrease in CVC was attenuated during heat stress (P < 0.01) while the absolute decrease in FVC was unaffected (P = 0.90). When CVC and FVC data were analyzed as a relative change from their respective baseline values, heat stress significantly attenuated the magnitude of vasoconstriction due to leg dependency in the cutaneous and femoral circulations (P < 0.001 for both variables). These data suggest that an attenuated local vasoconstriction, evoked via the venoarteriolar response, may contribute to reduced blood pressure control and thus reduced orthostatic tolerance that occurs in heat-stressed individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.