ArticleThe American journal of pathology2009
Unilateral blood flow decrease induces bilateral and symmetric responses in the immature brain.
Article in The American journal of pathology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Progressive inflammation reduces high-frequency EEG activity and cortical dendritic arborisation in late gestation fetal sheep.Journal of neuroinflammation · 2023Article
- Collateral Supply in Preclinical Cerebral Stroke Models.Translational stroke research · 2022Review
- Poly(ADP-Ribose) Polymerase Inhibitor PJ34 Reduces Brain Damage after Stroke in the Neonatal Mouse Brain.Current issues in molecular biology · 2021Article
- High-Dose Melatonin and Ethanol Excipient Combined with Therapeutic Hypothermia in a Newborn Piglet Asphyxia Model.Scientific reports · 2020Article
- Proton Magnetic Resonance Spectroscopy Lactate/N-Acetylaspartate Within 48 h Predicts Cell Death Following Varied Neuroprotective Interventions in a Piglet Model of Hypoxia-Ischemia With and Without Inflammation-Sensitization.Frontiers in neurology · 2020Article
- Acute LPS sensitization and continuous infusion exacerbates hypoxic brain injury in a piglet model of neonatal encephalopathy.Scientific reports · 2019Article
- A Model of Perinatal Ischemic Stroke in the Rat: 20 Years Already and What Lessons?Frontiers in neurology · 2018Review
- Protective Effect of Ischemic Preconditioning on Myocardium Against Remote Tissue Injury Following Transient Focal Cerebral Ischemia in Diabetic Rats.Arquivos brasileiros de cardiologia · 2017Article
- Neurorestoration after traumatic brain injury through angiotensin II receptor blockage.Brain : a journal of neurology · 2015Article
- Hepatic expression of serum amyloid A1 is induced by traumatic brain injury and modulated by telmisartan.The American journal of pathology · 2015Article
- Temporal dynamics of cerebral blood flow, cortical damage, apoptosis, astrocyte-vasculature interaction and astrogliosis in the pericontusional region after traumatic brain injury.Frontiers in neurology · 2014Article
- Dynamic spatio-temporal imaging of early reflow in a neonatal rat stroke model.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2013Article
- Transient focal cerebral ischemia induces long-term cerebral vasculature dysfunction in a rodent experimental stroke model.Translational stroke research · 2012Article
- Intracortical injection of endothelin-1 induces cortical infarcts in mice: effect of neuronal expression of an adenosine transporter.Experimental & translational stroke medicine · 2012Article
- Targeting neonatal ischemic brain injury with a pentapeptide-based irreversible caspase inhibitor.Cell death & disease · 2011Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of hemodynamic changes in the developing brain have yet to be fully understood. The aim of this study was to explore the relationship between perturbations of the cerebral blood flow in the developing brain via unilateral hypoperfusion in P7 rats. As expected, nuclear caspase-3 (casp3) cleavage and DNA fragmentation were detected at 48 hours after stroke in the injured cortex. Surprisingly, casp3 was also cleaved in the contralateral cortex, although without cell death markers. Delayed (48 hours) casp3 cleavage without DNA fragmentation was also identified after unilateral common carotid artery occlusion, both in the hypoperfused cortex and the unaffected cortex, producing mirror images. Upstream calpain activation, caspase-2 cleavage, and mitochondrial cytochrome c release initiated casp3 cleavage, but did not produce preconditioning. The neuronal marker NeuN co-localized with cleaved casp3 in cortical layers II-III and VI and with gaba-amino butyric acid in layer III. Indeed, collateral supply was provided from the opposite side during carotid artery occlusion but not after reperfusion, and the number of cleaved casp3-positive cells significantly negatively correlated with the common carotid artery immediate reperfusion percentage. In summary, unilateral hypoperfusion, while insufficient to induce cell death, may active bilateral and symmetric casp3 in the P7 rat brain. Additionally, the opposite healthy hemisphere is altered due to the injury and thus should not be used as an internal control.
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