ArticleThe American journal of pathology2009
Nano-scaled particles of titanium dioxide convert benign mouse fibrosarcoma cells into aggressive tumor cells.
Article in The American journal of pathology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Titanium dioxide nanoparticles in oncology: synthesis, application, and challenges.Cell biology and toxicology · 2026Review
- The Influence of Blood Titanium Levels on DNA Damage in Brazilian Workers Occupationally Exposed to Different Chemical Agents.Biological trace element research · 2025Article
- Rising Influence of Nanotechnology in Addressing Oxidative Stress-Related Liver Disorders.Antioxidants (Basel, Switzerland) · 2023Review
- Metal-Based Nanoparticles and Their Relevant Consequences on Cytotoxicity Cascade and Induced Oxidative Stress.Antioxidants (Basel, Switzerland) · 2023Review
- Molecular relation between biological stress and carcinogenesis.Molecular biology reports · 2022Review
- Review
- Use of Protamine in Nanopharmaceuticals-A Review.Nanomaterials (Basel, Switzerland) · 2021Review
- Challenges in diagnosing aortic leiomyosarcoma post endovascular repair of abdominal aortic aneurysm.Journal of vascular surgery cases and innovative techniques · 2020Article
- Intravascular Epithelioid Angiosarcoma in the Abdominal Aorta Mimicking an Infected Aneurysm.Vascular specialist international · 2019Article
- Article
- Comparative cytotoxicity of respirable surface-treated/untreated calcium carbonate rock dust particles in vitro.Toxicology and applied pharmacology · 2019Article
- Ozone augments interleukin-8 production induced by ambient particulate matter.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2018Article
- Effect of Surface Functionalization on the Cellular Uptake and Toxicity of Nanozeolite A.Nanoscale research letters · 2016Article
- Intracellular calcium levels as screening tool for nanoparticle toxicity.Journal of applied toxicology : JAT · 2015Article
- Titanium dioxide nanoparticles: a review of current toxicological data.Particle and fibre toxicology · 2013Review
- Metabolic effects of TiO2 nanoparticles, a common component of sunscreens and cosmetics, on human keratinocytes.Cell death & disease · 2013Article
- The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles.International journal of nanomedicine · 2012Review
- Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Targeting solid tumors with non-pathogenic obligate anaerobic bacteria.Cancer science · 2010Review
- Carbon black and titanium dioxide nanoparticles elicit distinct apoptotic pathways in bronchial epithelial cells.Particle and fibre toxicology · 2010Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nanoparticles are prevalent in both commercial and medicinal products; however, the contribution of nanomaterials to carcinogenesis remains unclear. We therefore examined the effects of nano-sized titanium dioxide (TiO(2)) on poorly tumorigenic and nonmetastatic QR-32 fibrosarcoma cells. We found that mice that were cotransplanted subcutaneously with QR-32 cells and nano-sized TiO(2), either uncoated (TiO(2)-1, hydrophilic) or coated with stearic acid (TiO(2)-2, hydrophobic), did not form tumors. However, QR-32 cells became tumorigenic after injection into sites previously implanted with TiO(2)-1, but not TiO(2)-2, and these developing tumors acquired metastatic phenotypes. No differences were observed either histologically or in inflammatory cytokine mRNA expression between TiO(2)-1 and TiO(2)-2 treatments. However, TiO(2)-2, but not TiO(2)-1, generated high levels of reactive oxygen species (ROS) in cell-free conditions. Although both TiO(2)-1 and TiO(2)-2 resulted in intracellular ROS formation, TiO(2)-2 elicited a stronger response, resulting in cytotoxicity to the QR-32 cells. Moreover, TiO(2)-2, but not TiO(2)-1, led to the development of nuclear interstices and multinucleate cells. Cells that survived the TiO(2) toxicity acquired a tumorigenic phenotype. TiO(2)-induced ROS formation and its related cell injury were inhibited by the addition of antioxidant N-acetyl-l-cysteine. These results indicate that nano-sized TiO(2) has the potential to convert benign tumor cells into malignant ones through the generation of ROS in the target cells.
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