ArticleEarly human development2009
Decreased CD47 expression during spontaneous apoptosis targets neutrophils for phagocytosis by monocyte-derived macrophages.
Article in Early human development, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Inflammation: a matter of immune cell life and death.npj biomedical innovations · 2025Review
- Accumulation of free nuclei denotes defective phagocytic capacity of macrophages and occurs after infection withFrontiers in immunology · 2025Article
- Dietary Fish Oil Increases the Number of CD11bJournal of inflammation research · 2022Article
- Intratumoral SIRPα-deficient macrophages activate tumor antigen-specific cytotoxic T cells under radiotherapy.Nature communications · 2021Article
- Effect of vitamin E on stroke-associated pneumonia.The Journal of international medical research · 2020Article
- Docosahexaenoic Acid Modulates NK Cell Effects on Neutrophils and Their Crosstalk.Frontiers in immunology · 2020Article
- Regulation of Apoptotic Cell Clearance During Resolution of Inflammation.Frontiers in pharmacology · 2019Review
- The "Phagocytic Synapse" and Clearance of Apoptotic Cells.Frontiers in immunology · 2017Review
- Pathobiology of neutrophil-epithelial interactions.Immunological reviews · 2016Review
- Evidencing the Role of Erythrocytic Apoptosis in Malarial Anemia.Frontiers in cellular and infection microbiology · 2016Review
- Interplay between Cellular and Molecular Inflammatory Mediators in Lung Cancer.Mediators of inflammation · 2016Review
- ADAMTS-12 metalloprotease is necessary for normal inflammatory response.The Journal of biological chemistry · 2012Article
- Neutrophil clearance: when the party is over, clean-up begins.Trends in immunology · 2011Review
- Thrombospondin-1: multiple paths to inflammation.Mediators of inflammation · 2011Review
- Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47.Science translational medicine · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundNeutrophils (PMN) are the primary leukocyte responders during acute inflammation. After migrating into the tissues, PMN undergo programmed cell death (apoptosis) and are subsequently removed via phagocytosis by resident macrophages during the resolution phase. Efficient phagocytosis of apoptotic neutrophils is necessary for successful resolution. CD47 plays a critical role in mediating the phagocytic response, although its role in the phagocytosis of apoptotic PMN is incompletely understood.
aimsIn the present study we tested the hypotheses that CD47 modulates the targeting of apoptotic PMN for phagocytosis, and that this process is altered in neonatal PMN. STUDY
designAdult and neonatal PMN were examined for their expression of CD47. To investigate CD47-mediated functions, apoptotic adult and neonatal PMN were co-cultured with monocyte-derived macrophages (MDM) and the phagocytic index was determined using a flow cytometry-based assay.
resultsWe observed lower basal surface CD47 levels on neonatal vs. adult PMN. In both groups, spontaneous apoptosis led to decreased surface and total cellular CD47 expression. Adult and neonatal MDM ingested apoptotic neonatal target PMN more avidly than apoptotic adult target PMN. Masking of surface CD47 on PMN with a monoclonal antibody enhanced MDM phagocytic activity.
conclusionsOur results suggest that age-dependent expression of CD47 on PMN may account for differences in their ingestion by macrophages and in the resolution of inflammation.
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Registered trials
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