ReviewJournal of biomechanics2010
Emergent morphogenesis: elastic mechanics of a self-deforming tissue.
Review in Journal of biomechanics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Engineering anisotropic tissues: from structured scaffolds to magnetic actuation.Materials today. Bio · 2026Review
- Neighbor cells restrain furrowing during Xenopus epithelial cytokinesis.Developmental cell · 2025Article
- Dynamic forces drive cell and organ morphology changes during embryonic development.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- An actin bracket-induced elastoplastic transition determines epithelial folding irreversibility.Nature communications · 2024Article
- Article
- Conserved physical mechanisms of cell and tissue elongation.Development (Cambridge, England) · 2024Review
- Age-progressive interplay of HSP-proteostasis, ECM-cell junctions and biomechanics ensures C. elegans astroglial architecture.Nature communications · 2024Article
- Information integration during bioelectric regulation of morphogenesis of the embryonic frog brain.iScience · 2023Article
- Time-lapse mechanical imaging of neural tube closure in live embryo using Brillouin microscopy.Scientific reports · 2023Article
- Autophagy coordinates chondrocyte development and early joint formation in zebrafish.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Shaping the Organ: A Biologist Guide to Quantitative Models of Plant Morphogenesis.Frontiers in plant science · 2021Review
- Tissue biomechanics during cranial neural tube closure measured by Brillouin microscopy and optical coherence tomography.Birth defects research · 2019Article
- The Cognitive Lens: a primer on conceptual tools for analysing information processing in developmental and regenerative morphogenesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- Physics of growing biological tissues: the complex cross-talk between cell activity, growth and resistance.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2019Review
- Vangl2-dependent regulation of membrane protrusions and directed migration requires a fibronectin extracellular matrix.Development (Cambridge, England) · 2018Article
- Membrane trafficking in morphogenesis and planar polarity.Traffic (Copenhagen, Denmark) · 2018Review
- The bioelectric code: An ancient computational medium for dynamic control of growth and form.Bio Systems · 2018Review
- Mechanocellular models of epithelial morphogenesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Mechanics of neurulation: From classical to current perspectives on the physical mechanics that shape, fold, and form the neural tube.Birth defects research · 2017Review
- Non-straight cell edges are important to invasion and engulfment as demonstrated by cell mechanics model.Biomechanics and modeling in mechanobiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Multicellular organisms are generated by coordinated cell movements during morphogenesis. Convergent extension is a key tissue movement that organizes mesoderm, ectoderm, and endoderm in vertebrate embryos. The goals of researchers studying convergent extension, and morphogenesis in general, include understanding the molecular pathways that control cell identity, establish fields of cell types, and regulate cell behaviors. Cell identity, the size and boundaries of tissues, and the behaviors exhibited by those cells shape the developing embryo; however, there is a fundamental gap between understanding the molecular pathways that control processes within single cells and understanding how cells work together to assemble multicellular structures. Theoretical and experimental biomechanics of embryonic tissues are increasingly being used to bridge that gap. The efforts to map molecular pathways and the mechanical processes underlying morphogenesis are crucial to understanding: (1) the source of birth defects, (2) the formation of tumors and progression of cancer, and (3) basic principles of tissue engineering. In this paper, we first review the process of tissue convergent extension of the vertebrate axis and then review models used to study the self-organizing movements from a mechanical perspective. We conclude by presenting a relatively simple "wedge-model" that exhibits key emergent properties of convergent extension such as the coupling between tissue stiffness, cell intercalation forces, and tissue elongation forces.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.