ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2009
The R753Q polymorphism abrogates toll-like receptor 2 signaling in response to human cytomegalovirus.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Gene variants associated with acne vulgaris presentation and severity: a systematic review and meta-analysis.BMC medical genomics · 2021Pooled it
- Host genetics and susceptibility to congenital and childhood cytomegalovirus infection: a systematic review.Croatian medical journal · 2016Pooled it
- IL-12-producing monocytes and HLA-E control HCMV-driven NKG2C+ NK cell expansion.The Journal of clinical investigation · 2014Trial
- Scratching the Surface Takes a Toll: Immune Recognition of Viral Proteins by Surface Toll-like Receptors.Viruses · 2022Review
- Polygenic Innate Immunity Score to Predict the Risk of Cytomegalovirus Infection in CMV D+/R- Transplant Recipients. A Prospective Multicenter Cohort Study.Frontiers in immunology · 2022Article
- The Immunogenetics of Acne.Advances in experimental medicine and biology · 2022Article
- Toll-like receptor-mediated innate immunity against herpesviridae infection: a current perspective on viral infection signaling pathways.Virology journal · 2020Review
- Interrelationship between Toll-like receptors and infection after orthotopic liver transplantation.World journal of transplantation · 2020Review
- Genetic and Functional Characterization of Toll-Like Receptor Responses in Immunocompetent Patients With CMV Mononucleosis.Frontiers in cellular and infection microbiology · 2020Article
- Toll-like receptors genes polymorphisms and the occurrence of HCMV infection among pregnant women.Virology journal · 2017Article
- TLR2 2258 G>A single nucleotide polymorphism and the risk of congenital infection with human cytomegalovirus.Virology journal · 2017Article
- Herpesvirus Respiratory Infections in Immunocompromised Patients: Epidemiology, Management, and Outcomes.Seminars in respiratory and critical care medicine · 2016Review
- Role of cytomegalovirus on the maturation and function of monocyte derived dendritic cells of liver transplant patients.World journal of transplantation · 2016Article
- TLR9 -1486T/C and 2848C/T SNPs Are Associated with Human Cytomegalovirus Infection in Infants.PloS one · 2016Article
- Human Cytomegalovirus miR-UL112-3p Targets TLR2 and Modulates the TLR2/IRAK1/NFκB Signaling Pathway.PLoS pathogens · 2015Article
- Infections after orthotopic liver transplantation.Journal of clinical and experimental hepatology · 2014Review
- Genetic variants of innate immune receptors and infections after liver transplantation.World journal of gastroenterology · 2014Review
- Cytomegalovirus infection in liver transplant recipients: updates on clinical management.World journal of gastroenterology · 2014Review
- Association of Toll-like receptor 2 polymorphisms with gout.Biomedical reports · 2014Article
- Homozygosity for the toll-like receptor 2 R753Q single-nucleotide polymorphism is a risk factor for cytomegalovirus disease after liver transplantation.The Journal of infectious diseases · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Toll-like receptor 2 (TLR2) serves as a pattern recognition receptor that signals the presence of cytomegalovirus. Herein, we report that R753Q polymorphism paralyzes TLR2-mediated immune signaling in cells exposed to cytomegalovirus glycoprotein B. This immunologic impairment could serve as a biologic mechanism underlying the association between the TLR2 R753Q polymorphism and cytomegalovirus disease in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.