ReviewDrugs1990
Cetirizine. A review of its pharmacological properties and clinical potential in allergic rhinitis, pollen-induced asthma, and chronic urticaria.
Review in Drugs, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 144 citations in OpenAlex.
- A systematic review of patient-reported outcome instruments measuring sleep dysfunction in adults.PharmacoEconomics · 2005Pooled it
- Pooled it
- Histamine H1 receptor antagonist cetirizine impairs working memory processing speed, but not episodic memory.British journal of pharmacology · 2010Trial
- Comparative activity of cetirizine and mizolastine on histamine-induced skin wheal and flare responses at 24 h.British journal of clinical pharmacology · 2002Trial
- Pharmacokinetics of cetirizine in tear fluid after a single oral dose.Clinical pharmacokinetics · 2002Trial
- Microinjection technique for pharmacological evaluation of microvascular permeability in human skin.European journal of clinical pharmacology · 1996Trial
- Lack of interaction between two antihistamines, mizolastine and cetirizine, and ethanol in psychomotor and driving performance in healthy subjects.European journal of clinical pharmacology · 1995Trial
- Effect of longterm cetirizine treatment on the cutaneous hypersensitivity reaction in patients with grass pollen allergy.European journal of clinical pharmacology · 1994Trial
- Effects of loratadine and cetirizine on actual driving and psychometric test performance, and EEG during driving.European journal of clinical pharmacology · 1992Trial
- Ultra-Sensitive and Validated method for Trace Quantification of Carcinogenic Benzene in Cetirizine Dihydrochloride.Biomedical chromatography : BMC · 2026Article
- Development of green purification process for piperazine-type drugs: a case study of quetiapine process development.RSC advances · 2026Article
- Distribution of pharmaceuticals in marine surface sediment and macroalgae (ulvophyceae) around Mombasa peri-urban creeks and Gazi Bay, Kenya.Environmental science and pollution research international · 2025Article
- Prescribed drugs containing nitrogen heterocycles: an overview.RSC advances · 2020Review
- Rigid Scaffolds: Synthesis of 2,6-Bridged Piperazines with Functional Groups in all three Bridges.ChemistryOpen · 2020Article
- Cetirizine-induced hepatotoxicity: case series and review of the literature.Gastroenterology report · 2018Article
- Open-label, add-on trial of cetirizine for neuromyelitis optica.Neurology(R) neuroimmunology & neuroinflammation · 2018Article
- Predictive Performance of Physiologically Based Pharmacokinetic and Population Pharmacokinetic Modeling of Renally Cleared Drugs in Children.CPT: pharmacometrics & systems pharmacology · 2016Article
- The H1-receptor antagonist cetirizine ameliorates high-fat diet-induced glucose intolerance in male C57BL/6 mice, but not diabetes outcome in female non-obese diabetic (NOD) mice.Upsala journal of medical sciences · 2015Article
- Development of novel elastic vesicle-based topical formulation of cetirizine dihydrochloride for treatment of atopic dermatitis.AAPS PharmSciTech · 2013Article
- Effects of histamine on cultured interstitial cells of cajal in murine small intestine.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cetirizine, a piperazine derivative and carboxylated metabolite of hydroxyzine, is a potent histamine H1-receptor antagonist with antiallergic properties. It has marked affinity for peripheral histamine H1-receptors and, at the standard dose of 10mg daily, lacks the CNS depressant effects of standard antihistamines. In addition, it inhibits histamine release and eosinophil chemotaxis during the secondary phase of the allergic response. Results from controlled clinical trials indicate that cetirizine is an effective and well tolerated treatment of seasonal and perennial allergic rhinitis and chronic idiopathic urticaria. Cetirizine appears to be as effective as conventional dosages of terfenadine, chlorpheniramine and hydroxyzine in relieving symptoms associated with these disorders and produces a markedly lower incidence of sedation than chlorpheniramine, hydroxyzine and several other standard antihistamines. Thus, cetirizine appears to provide a useful alternative to other 'nonsedating' antihistamines; cetirizine may also have a future role in the treatment of allergic asthma and certain forms of physical urticaria.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.