ArticleDevelopmental neurobiology2009
Convergence of multisensory inputs in Xenopus tadpole tectum.
Article in Developmental neurobiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Assessing circuit function in the developingFrontiers in behavioral neuroscience · 2026Review
- Activity-dependent Organization of Topographic Neural Circuits.Neuroscience · 2023Review
- Tetrode Recording in theCold Spring Harbor protocols · 2021Article
- Xenopus leads the way: Frogs as a pioneering model to understand the human brain.Genesis (New York, N.Y. : 2000) · 2021Review
- Neural Design Principles for Subjective Experience: Implications for Insects.Frontiers in behavioral neuroscience · 2021Article
- Experience, circuit dynamics, and forebrain recruitment in larval zebrafish prey capture.eLife · 2020Article
- Influence of Stimulus Intensity on Multimodal Integration in the Startle Escape System of Goldfish.Frontiers in neural circuits · 2019Article
- Presenilin Regulates Retinotectal Synapse Formation through EphB2 Receptor Processing.Developmental neurobiology · 2018Article
- Direct intertectal inputs are an integral component of the bilateral sensorimotor circuit for behavior in Xenopus tadpoles.Journal of neurophysiology · 2018Article
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- Experience-dependent plasticity of excitatory and inhibitory intertectal inputs in Xenopus tadpoles.Journal of neurophysiology · 2016Article
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- An Evolutionarily Conserved Mechanism for Activity-Dependent Visual Circuit Development.Frontiers in neural circuits · 2016Review
- The horizontal brain slice preparation: a novel approach for visualizing and recording from all layers of the tadpole tectum.Journal of neurophysiology · 2015Article
- Modeling human neurodevelopmental disorders in the Xenopus tadpole: from mechanisms to therapeutic targets.Disease models & mechanisms · 2013Review
- Global hyper-synchronous spontaneous activity in the developing optic tectum.Scientific reports · 2013Article
- Visual experience-dependent maturation of correlated neuronal activity patterns in a developing visual system.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Sensory modality-specific homeostatic plasticity in the developing optic tectum.Nature neuroscience · 2011Article
- Focusing on optic tectum circuitry through the lens of genetics.BMC biology · 2010Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The integration of multisensory information takes place in the optic tectum where visual and auditory/mechanosensory inputs converge and regulate motor outputs. The circuits that integrate multisensory information are poorly understood. In an effort to identify the basic components of a multisensory integrative circuit, we determined the projections of the mechanosensory input from the periphery to the optic tectum and compared their distribution to the retinotectal inputs in Xenopus laevis tadpoles using dye-labeling methods. The peripheral ganglia of the lateral line system project to the ipsilateral hindbrain and the axons representing mechanosensory inputs along the anterior/posterior body axis are mapped along the ventrodorsal axis in the axon tract in the dorsal column of the hindbrain. Hindbrain neurons project axons to the contralateral optic tectum. The neurons from anterior and posterior hindbrain regions project axons to the dorsal and ventral tectum, respectively. While the retinotectal axons project to a superficial lamina in the tectal neuropil, the hindbrain axons project to a deep neuropil layer. Calcium imaging showed that multimodal inputs converge on tectal neurons. The layer-specific projections of the hindbrain and retinal axons suggest a functional segregation of sensory inputs to proximal and distal tectal cell dendrites, respectively.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.