Evidence map›Paper›PMID 19812438›Full record

ArticleAntiviral therapy2009

Oxidant stress in HIV-infected women from the Women's Interagency HIV Study.

Marshall J Glesby, Donald R Hoover, Farbod Raiszadeh, Irene Lee, Qiuhu Shi, Ginger Milne, Stephanie C Sanchez, Wei Gao, Robert C Kaplan, Jason D Morrow and 1 more

Abstract read
In one paragraph

Article in Antiviral therapy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Higher serum iron is associated with increased oxidant stress in HIV-infected men.Journal of acquired immune deficiency syndromes (1999) · 2013
    Article
  6. Article
  7. Article
  8. Article
  9. Isoprostane generation and function.Chemical reviews · 2011
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Marshall J GlesbyDivision of Infectious Diseases, Department of Medicine, Weill Cornell Medical College, New York, NY, USA. mag2005@med.cornell.edu
Donald R Hoover
Farbod Raiszadeh
Irene Lee
Qiuhu Shi
Ginger Milne
Stephanie C Sanchez
Wei Gao
Robert C Kaplan
Jason D Morrow
Kathryn Anastos
Albert Einstein College of Medicine · USVanderbilt University Medical Center · USCornell University · USMedidata (United States) · USNew York Medical College · USRutgers, The State University of New Jersey · USSt. Luke's-Roosevelt Hospital Center · US

Funding

Women's Interagency HIV Study (WIHS-V)U01AI035004 · NIAID · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI ANASTOS, KATHRYN M., SHARMA, ANJALI · 1993 to 2018
$65.7M
Immunology/Pathology CoreP30AI051519 · NIAID · YESHIVA UNIVERSITY · PI GOLDSTEIN, HARRIS · 2003 to 2013
$18.6M
THE PHARMACOLOGY OF INHIBITORS OF HEME PROTEIN-CATALYZED LIPID PEROXIDATIONP50GM015431 · NIGMS · VANDERBILT UNIVERSITY · PI CAPRIOLI, RICHARD M · 1985 to 2010
$15.0M
Protein Adducts and Proteome Profiles in Oxidative StressP01ES013125 · NIEHS · VANDERBILT UNIVERSITY · PI BROWN, H. ALEX · 2005 to 2012
$12.6M
Role of innate immunity in HIV related vascular disease: biomarkers & mechanismsR01HL126543 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KAPLAN, ROBERT C · 2014 to 2017
$3.7M
Mechanisms of Atherosclerosis and CVD in HIV+ WomenR01HL083760 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI KAPLAN, ROBERT C · 2006 to 2009
$2.5M
BIOCHEMISTRY AND PHARMACOLOGY OF D2/E2-ISOPROSTANESR01DK048831 · NIDDK · VANDERBILT UNIVERSITY · PI YIN, HUIYONG · 1995 to 2008
$2.2M
METABOLIC EFFECTS OF PROTEASE INHIBITORS IN HIV DISEASER01DK054615 · NIDDK · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI MULLIGAN, KATHLEEN · 1998 to 2002
$1.0M
Complications of Chronic Viral InfectionsK24AI078884 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI GLESBY, MARSHALL J · 2008 to 2012
$892k
NHLBI NIH HHS R01 HL083760NHLBI NIH HHS R01 HL126543NIAID NIH HHS AI51519NIAID NIH HHS K24 AI078884NIAID NIH HHS K24 AI 78884NIAID NIH HHS P30 AI051519NIAID NIH HHS U01 AI035004NIAID NIH HHS UO1-AI35004NIDDK NIH HHS DK54615NIDDK NIH HHS R01 DK048831NIDDK NIH HHS R01 DK054615NIDDK NIH HHS R01 DK48831NIEHS NIH HHS P01 ES013125NIEHS NIH HHS P01 ES13125NIGMS NIH HHS P50 GM015431NIGMS NIH HHS P50 GM15430
6 · The paper itself

Abstract

backgroundOxidant stress contributes to the pathogenesis of multiple conditions and can be assessed by measuring plasma F(2)-isoprostane concentrations. We hypothesized that oxidant stress is associated with plasma homocysteine concentration and risk factors for atherosclerosis in HIV-infected women.

methodsWe measured plasma F(2)-isoprostane concentrations in a cross-sectional study of 249 HIV-infected women attending the Bronx (NY, USA) site of the Women's Interagency HIV Study and assessed associations with plasma homocysteine concentration and other metabolic parameters by linear regression.

resultsIn multivariate analysis, hepatitis C virus (HCV) viraemia, waist circumference, homocysteine concentration and serum aspartate aminotransferase level were positively associated with log F(2)-isoprostane concentration (all P<0.005). There was a trend for an inverse association between log F(2)-isoprostane and CD4(+) T-cell percentage (P=0.06). Among women with HCV infection, the FIB-4 index, an indirect marker of liver fibrosis derived from routine laboratory tests, was positively associated with log F(2)-isoprostane concentration.

conclusionsIn this cross-sectional study of HIV-infected women, plasma F(2)-isoprostane concentration was positively associated with homocysteine concentration, as well as HCV infection, abdominal obesity and aspartate aminotransferase level.

Indexed as

AdultAtherosclerosisCross-Sectional StudiesF2-IsoprostanesFemaleHIV InfectionsHomocysteineHumansMiddle AgedOxidantsOxidative StressRisk FactorsF2-IsoprostanesHomocysteineOxidants

Identifiers

PMID19812438
PMCPMC2760028
OpenAlexW2000189074

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.