ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2009
The role of aldosterone in mediating the dependence of angiotensin hypertension on IL-6.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 33 citations in OpenAlex.
- Acid-sensing ion channel 1a deficiency drives endocrine hypertension in male mice.The Journal of physiology · 2026Article
- Targeting inerleukin-6 for renoprotection.Frontiers in immunology · 2024Review
- Renal Medullary Overexpression of Sphingosine-1-Phosphate Receptor 1 Transgene Attenuates Deoxycorticosterone Acetate (DOCA)-Salt Hypertension.American journal of hypertension · 2023Article
- Interleukin 17A infusion has no acute or long-term hypertensive action in conscious unrestrained male mice.Pflugers Archiv : European journal of physiology · 2022Article
- Inflammation and oxidative stress in salt sensitive hypertension; The role of the NLRP3 inflammasome.Frontiers in physiology · 2022Review
- Detrimental role of sphingosine kinase 1 in kidney damage in DOCA-salt hypertensive model: evidence from knockout mice.BMC nephrology · 2020Article
- ADAM17-Mediated Shedding of Inflammatory Cytokines in Hypertension.Frontiers in pharmacology · 2020Review
- Endothelial Dysfunction in Primary Aldosteronism.International journal of molecular sciences · 2019Review
- Augmented astrocyte microdomain CaGlia · 2019Article
- Collagen biomarker bioprofiles predicting the antifibrotic response to eplerenone in myocardial infarction: findings from the REMINDER trial.Clinical research in cardiology : official journal of the German Cardiac Society · 2018Article
- Inflammatory Signaling in Hypertension: Regulation of Adrenal Catecholamine Biosynthesis.Frontiers in endocrinology · 2018Review
- Autonomic regulation of the immune system in cardiovascular diseases.Advances in physiology education · 2017Review
- Cellular and Oxidative Mechanisms Associated with Interleukin-6 Signaling in the Vasculature.International journal of molecular sciences · 2017Review
- Role of the Immune System in Hypertension.Physiological reviews · 2017Review
- Interleukin-6 inhibition attenuates hypertension and associated renal damage in Dahl salt-sensitive rats.American journal of physiology. Renal physiology · 2016Article
- Dysregulation of T cell subsets in the pathogenesis of hypertension.Current hypertension reports · 2015Review
- Impact of aldosterone antagonists on the substrate for atrial fibrillation: aldosterone promotes oxidative stress and atrial structural/electrical remodeling.International journal of cardiology · 2013Review
- Effects of heme oxygenase-1 upregulation on blood pressure and cardiac function in an animal model of hypertensive myocardial infarction.International journal of molecular sciences · 2013Article
- Vascular inflammatory cells in hypertension.Frontiers in physiology · 2012Article
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4 authors at 1 institution in 1 country.
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Abstract
Knockout (KO) of IL-6 has been shown to attenuate ANG II hypertension, and mineralocorticoid receptors (MR) have been reported to contribute to the increase in IL-6 during acute ANG II infusion. This study determined whether that MR action is sustained with chronic ANG II infusion and whether it plays a role in mediating ANG II hypertension. ANG II infusion (90 ng/min) increased plasma IL-6 from 1.6 +/- 0.6 to 22.7 +/- 2.2 and 19.9 +/- 3.2 pg/ml on days 7 and 14, respectively, and chronic MR blockade with spironolactone attenuated that only at day 7 (7.2 +/- 2.2 pg/ml). ANG II increased MAP (19 h/day with telemetry) approximately 40 mmHg, but in ANG II+spironolactone mice (25 or 50 mg*kg(-1)*day(-1)), mean arterial pressure (MAP) was not significantly different despite a tendency for lower pressure the first 6 days. To isolate further the mineralocorticoid link to IL-6 and blood pressure, DOCA-salt hypertension was induced in IL-6 KO and wild-type (WT) mice. Plasma IL-6 increased from 4.1 +/- 1.7 to 34.5 +/- 7.0 pg/ml by day 7 of DOCA treatment in the WT mice but was back to control levels by day 14. An IL-6 bioassay using the murine B9, B-cell hybridoma cell line demonstrated that plasma IL-6 measurements reflected actual IL-6 bioactivity. The hypertension was not different and virtually superimposable in WT vs. IL-6 KO mice, averaging 145 +/- 2 and 144 +/- 3 mmHg, respectively. Both experiments confirm chronic stimulation of IL-6 by mineralocorticoids but show that it is transient. In addition, IL-6 was not required for mineralocorticoid hypertension. This suggests that aldosterone contributes to the increase in plasma IL-6 in the early stage of ANG II hypertension but that the blood pressure actions of IL-6 in that model are linked most likely to ANG II rather than aldosterone.
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