ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Sonic hedgehog regulates integrin activity, cadherin contacts, and cell polarity to orchestrate neural tube morphogenesis.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- RXR Gamma Enables Oligodendrocyte Differentiation by Suppressing Sonic Hedgehog Signaling.Glia · 2026Article
- Engineering human neuronal diversity: Morphogens and stem cell technologies for neurodevelopmental biology.Stem cell reports · 2025Review
- Myosin II mediates Shh signals to shape dental epithelia via control of cell adhesion and movement.PLoS genetics · 2024Article
- Ihog proteins contribute to integrin-mediated focal adhesions.Science China. Life sciences · 2023Article
- Cadherins and catenins in cancer: connecting cancer pathways and tumor microenvironment.Frontiers in cell and developmental biology · 2023Review
- Transcriptional Control of Apical-Basal Polarity Regulators.International journal of molecular sciences · 2021Review
- Basal epidermis collective migration and local Sonic hedgehog signaling promote skeletal branching morphogenesis in zebrafish fins.Developmental biology · 2021Article
- Sonic hedgehog signaling directs patterned cell remodeling during cranial neural tube closure.eLife · 2020Article
- Functionally Distinctive Ptch Receptors Establish Multimodal Hedgehog Signaling in the Tooth Epithelial Stem Cell Niche.Stem cells (Dayton, Ohio) · 2019Article
- G-protein-coupled receptor signaling and neural tube closure defects.Birth defects research · 2017Review
- Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development.Scientific reports · 2016Article
- A Robust Single Primate Neuroepithelial Cell Clonal Expansion System for Neural Tube Development and Disease Studies.Stem cell reports · 2016Article
- Stable and bicistronic expression of two genes in somite- and lateral plate-derived tissues to study chick limb development.BMC developmental biology · 2015Article
- N-cadherin sustains motility and polarity of future cortical interneurons during tangential migration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Altered methylation of IGF2 DMR0 is associated with neural tube defects.Molecular and cellular biochemistry · 2013Article
- Sonic hedgehog regulates osteoblast function by focal adhesion kinase signaling in the process of fracture healing.PloS one · 2013Article
- Astroglial integrins in the development and regulation of neurovascular units.Pain research and treatment · 2012Article
- MicroRNA gene expression signatures in the developing neural tube.Birth defects research. Part A, Clinical and molecular teratology · 2011Article
- Atypical protein kinase C (aPKCzeta and aPKClambda) is dispensable for mammalian hematopoietic stem cell activity and blood formation.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- N-cadherin-mediated cell adhesion restricts cell proliferation in the dorsal neural tube.Molecular biology of the cell · 2011Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In vertebrates, the embryonic nervous system is shaped and patterned by a series of temporally and spatially regulated cell divisions, cell specifications, and cell adhesions and movements. Morphogens of the Hedgehog, Wnt, and bone morphogenetic protein families have been shown to play a crucial role in the control of cell division and specification in the trunk neural tube, but their possible implication in the regulation of adhesive events has been poorly documented. In the present study, we demonstrate that Sonic hedgehog regulates neural epithelial cell adhesion and polarity through regulation of integrin activity, cadherin cell-cell contact, and cell polarity genes in immature neural epithelial cells before the specification of neuronal cells. We propose that Sonic hedgehog orchestrates neural tube morphogenesis by coordinating adhesive and motility events with cell proliferation and differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.