ArticleMolecular biology of the cell2009
Dcp1-bodies in mouse oocytes.
Article in Molecular biology of the cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 51 citations in OpenAlex.
- Pan2-Pan3 Complex-Mediated Deadenylation Enforces mRNA Quality Control for Infection of the Rice Blast Fungus.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Blunted Lsm14b activation disrupts maternal mRNA remodeling during the GV-to-MII transition in a mouse model of polycystic ovary syndrome.Frontiers in cell and developmental biology · 2026Article
- Diverse roles of stress-responsive RNP granules in oogenesis and infertility.Biology of reproduction · 2025Review
- Mutational analysis of the functional motifs of the DEAD-box RNA helicase Me31B/DDX6 in Drosophila germline development.FEBS letters · 2023Article
- P-bodies directly regulate MARF1-mediated mRNA decay in human cells.Nucleic acids research · 2022Article
- Review
- Article
- Using Single Molecule mRNA Fluorescent in Situ Hybridization (RNA-FISH) to Quantify mRNAs in Individual Murine Oocytes and Embryos.Scientific reports · 2018Article
- PATL2 is a key actor of oocyte maturation whose invalidation causes infertility in women and mice.EMBO molecular medicine · 2018Article
- CNOT6 regulates a novel pattern of mRNA deadenylation during oocyte meiotic maturation.Scientific reports · 2018Article
- Translational Control in the Latency of Apicomplexan Parasites.Trends in parasitology · 2017Review
- Cumulus Cell Transcripts Transit to the Bovine Oocyte in Preparation for Maturation.Biology of reproduction · 2016Article
- Distinct subcellular localization and potential role of LINE1-ORF1P in meiotic oocytes.Histochemistry and cell biology · 2016Article
- Temporal expression profiling identifies pathways mediating effect of causal variant on phenotype.PLoS genetics · 2015Article
- HAX-1: a novel p-body protein.DNA and cell biology · 2015Article
- Identification and characterization of a drug-sensitive strain enables puromycin-based translational assays in Saccharomyces cerevisiae.Yeast (Chichester, England) · 2014Article
- Cyclin B1 mRNA translation is temporally controlled through formation and disassembly of RNA granules.The Journal of cell biology · 2013Article
- Maternally recruited DCP1A and DCP2 contribute to messenger RNA degradation during oocyte maturation and genome activation in mouse.Biology of reproduction · 2013Article
- Genome-wide analysis of GLD-1-mediated mRNA regulation suggests a role in mRNA storage.PLoS genetics · 2012Article
- New insights into the regulation of RNP granule assembly in oocytes.International review of cell and molecular biology · 2012Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Processing bodies (P-bodies) are cytoplasmic granules involved in the storage and degradation of mRNAs. In somatic cells, their formation involves miRNA-mediated mRNA silencing. Many P-body protein components are also found in germ cell granules, such as in mammalian spermatocytes. In fully grown mammalian oocytes, where changes in gene expression depend entirely on translational control, RNA granules have not as yet been characterized. Here we show the presence of P-body-like foci in mouse oocytes, as revealed by the presence of Dcp1a and the colocalization of RNA-associated protein 55 (RAP55) and the DEAD box RNA helicase Rck/p54, two proteins associated with P-bodies and translational control. These P-body-like structures have been called Dcp1-bodies and in meiotically arrested primary oocytes, two types can be distinguished based on their size. They also have different protein partners and sensitivities to the depletion of endogenous siRNA/miRNA and translational inhibitors. However, both type progressively disappear during in vitro meiotic maturation and are virtually absent in metaphase II-arrested secondary oocytes. Moreover, this disassembly of hDcp1a-bodies is concomitant with the posttranslational modification of EGFP-hDcp1a.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.