ArticleMolecular biology of the cell2009
RhoG promotes neural progenitor cell proliferation in mouse cerebral cortex.
Article in Molecular biology of the cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- FTO promotes human NK cell proliferation yet restricts effector functions.Acta pharmacologica Sinica · 2026Article
- EphA2 and EGFR: Friends in Life, Partners in Crime. Can EphA2 Be a Predictive Biomarker of Response to Anti-EGFR Agents?Cancers · 2021Review
- Programmed Epigenetic DNA Methylation-Mediated Reduced Neuroprogenitor Cell Proliferation and Differentiation in Small-for-Gestational-Age Offspring.Neuroscience · 2019Article
- Review
- Nasal delivery of Fasudil-modified immune cells exhibits therapeutic potential in experimental autoimmune encephalomyelitis.CNS neuroscience & therapeutics · 2019Article
- The Intermolecular Interaction of Ephexin4 Leads to Autoinhibition by Impeding Binding of RhoG.Cells · 2018Article
- Article
- The therapeutic potential of Rho kinase inhibitor fasudil derivative FaD-1 in experimental autoimmune encephalomyelitis.Journal of molecular neuroscience : MN · 2015Article
- Host response profile of human brain proteome in toxoplasma encephalitis co-infected with HIV.Clinical proteomics · 2014Article
- Regulation of cerebral cortex development by Rho GTPases: insights from in vivo studies.Frontiers in cellular neuroscience · 2014Review
- Ephexin4-mediated promotion of cell migration and anoikis resistance is regulated by serine 897 phosphorylation of EphA2.FEBS open bio · 2013Article
- Mitochondrial superoxide production negatively regulates neural progenitor proliferation and cerebral cortical development.Stem cells (Dayton, Ohio) · 2012Article
- The small GTPase RhoG mediates glioblastoma cell invasion.Molecular cancer · 2012Article
- miR-124-regulated RhoG reduces neuronal process complexity via ELMO/Dock180/Rac1 and Cdc42 signalling.The EMBO journal · 2012Article
- Effect of Rho-kinase pathway on neurite outgrowth of rat hippocampal neurons under atomic force microscopy.Neural regeneration research · 2012Article
- The invasive capacity of HPV transformed cells requires the hDlg-dependent enhancement of SGEF/RhoG activity.PLoS pathogens · 2012Article
- The RhoG/ELMO1/Dock180 signaling module is required for spine morphogenesis in hippocampal neurons.The Journal of biological chemistry · 2011Article
- The F-BAR protein Rapostlin regulates dendritic spine formation in hippocampal neurons.The Journal of biological chemistry · 2011Article
- Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism.The Journal of cell biology · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In early cortical development, neural progenitor cells (NPCs) expand their population in the ventricular zone (VZ), and produce neurons. Although a series of studies have revealed the process of neurogenesis, the molecular mechanisms regulating NPC proliferation are still largely unknown. Here we found that RhoG, a member of Rho family GTPases, was expressed in the VZ at early stages of cortical development. Expression of constitutively active RhoG promoted NPC proliferation and incorporation of bromodeoxyuridine (BrdU) in vitro, and the proportion of Ki67-positive cells in vivo. In contrast, knockdown of RhoG by RNA interference suppressed the proliferation, BrdU incorporation, and the proportion of Ki67-positive cells in NPCs. However, knockdown of RhoG did not affect differentiation and survival of NPC. The RhoG-induced promotion of BrdU incorporation required phosphatidylinositol 3-kinase (PI3K) activity but not the interaction with ELMO. Taken together, these results indicate that RhoG promotes NPC proliferation through PI3K in cortical development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.