ArticleCerebral cortex (New York, N.Y. : 1991)2010
Role of late maternal thyroid hormones in cerebral cortex development: an experimental model for human prematurity.
Article in Cerebral cortex (New York, N.Y. : 1991), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 94 citations in OpenAlex.
- Impact of endocrine disrupting chemical exposure on thyroid disruption and oxidative stress in early pregnancy.Environmental analysis, health and toxicology · 2025Article
- Review
- Clinical indicators that influence a clinician's decision to start L-thyroxine treatment in prematurity with transient hypothyroxinemia.Italian journal of pediatrics · 2023Article
- Reducing uncertainties in quantitative adverse outcome pathways by analysis of thyroid hormone in the neonatal rat brain.Toxicological sciences : an official journal of the Society of Toxicology · 2023Article
- Thyroid hormone action controls multiple components of cell junctions at the ventricular zone in the newborn rat brain.Frontiers in endocrinology · 2023Article
- The Induction of Hypothyroidism during Gestation Decreases Outer Hair Cell Motility in Rat Offspring.International archives of otorhinolaryngology · 2022Article
- Factors Affecting Metabolic Bone Disease of Prematurity: Is Hypothyroxinemia Included?Sisli Etfal Hastanesi tip bulteni · 2022Review
- Article
- Thyroid hormone insufficiency alters the expression of psychiatric disorder-related molecules in the hypothyroid mouse brain during the early postnatal period.Scientific reports · 2021Article
- Thyroid disrupting chemicals and developmental neurotoxicity - New tools and approaches to evaluate hormone action.Molecular and cellular endocrinology · 2020Review
- Regulation of Thyroid-disrupting Chemicals to Protect the Developing Brain.Endocrinology · 2020Review
- Approaches to Dose Finding in Neonates, Illustrating the Variability between Neonatal Drug Development Programs.Pharmaceutics · 2020Article
- Phthalate and Bisphenol Exposure during Pregnancy and Offspring Nonverbal IQ.Environmental health perspectives · 2020Article
- Environmental Signals on Microglial Function during Brain Development, Neuroplasticity, and Disease.International journal of molecular sciences · 2020Review
- Transient Hypothyroidism During Lactation Alters the Development of the Corpus Callosum in Rats. AnFrontiers in neuroanatomy · 2020Article
- Monitoring Acute Stroke Progression: Multi-Parametric OCT Imaging of Cortical Perfusion, Flow, and Tissue Scattering in a Mouse Model of Permanent Focal Ischemia.IEEE transactions on medical imaging · 2019Article
- Thyroid Hormone Disruption in the Fetal and Neonatal Rat: Predictive Hormone Measures and Bioindicators of Hormone Action in the Developing Cortex.Toxicological sciences : an official journal of the Society of Toxicology · 2018Article
- Developmental Thyroid Hormone Insufficiency Induces a Cortical Brain Malformation and Learning Impairments: A Cross-Fostering Study.Toxicological sciences : an official journal of the Society of Toxicology · 2018Article
- Gestational Hypothyroxinemia Imprints a Switch in the Capacity of Astrocytes and Microglial Cells of the Offspring to React in Inflammation.Molecular neurobiology · 2018Article
- Transient Hypothyroidism During Lactation Arrests Myelination in the Anterior Commissure of Rats. A Magnetic Resonance Image and Electron Microscope Study.Frontiers in neuroanatomy · 2018Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypothyroxinemia affects 35-50% of neonates born prematurely (12% of births) and increases their risk of suffering neurodevelopmental alterations. We have developed an animal model to study the role of maternal thyroid hormones (THs) at the end of gestation on offspring's cerebral maturation. Pregnant rats were surgically thyroidectomized at embryonic day (E) 16 and infused with calcitonin and parathormone (late maternal hypothyroidism [LMH] rats). After birth, pups were nursed by normal rats. Pups born to LMH dams, thyroxine treated from E17 to postnatal day (P) 0, were also studied. In developing LMH pups, the cortical lamination was abnormal. At P40, heterotopic neurons were found in the subcortical white matter and in the hippocampal stratum oriens and alveus. The Zn-positive area of the stratum oriens of hippocampal CA3 was decreased by 41.5% showing altered mossy fibers' organization. LMH pups showed delayed learning in parallel to decreased phosphorylated cAMP response element-binding protein (pCREB) and phosphorylated extracellular signal-regulated kinase 1/2 (pERK1/2) expression in the hippocampus. Thyroxine treatment of LMH dams reverted abnormalities. In conclusion, maternal THs are still essential for normal offspring's neurodevelopment even after onset of fetal thyroid function. Our data suggest that thyroxine treatment of premature neonates should be attempted to compensate for the interruption of the maternal supply.
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