ArticleGenome research2009
Genome structure of a Saccharomyces cerevisiae strain widely used in bioethanol production.
Article in Genome research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers.
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Who cites it
106 citing papers in PubMed, 271 citations in OpenAlex.
- Comparative fermentability of a glucose/xylose enriched enzymatic slurry using different yeast strains.Bioprocess and biosystems engineering · 2026Article
- Comparative functional genomics ofMicrobiology spectrum · 2026Article
- Comparative analysis of phenotype and gene expression in Saccharomyces cerevisiae grown in solid versus liquid culture formats.BMC microbiology · 2026Article
- Repeated losses of self-fertility shaped heterozygosity and polyploidy in yeast evolution.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- From one genome to thousands, and beyond.FEMS yeast research · 2026Review
- Secure biosystems design inApplied and environmental microbiology · 2025Article
- Physiology and Robustness of Yeasts Exposed to Dynamic pH and Glucose Environments.Biotechnology and bioengineering · 2025Article
- Mycotoxin-free Aspergillus oryzae strain lineage for alternative and novel protein production at industrial scale.Applied microbiology and biotechnology · 2025Review
- Wild yeast isolation by middle-school students reveals features of populations residing on North American oaks.G3 (Bethesda, Md.) · 2025Article
- Wild yeast isolation by middle school students reveals features of North American oak populations ofbioRxiv : the preprint server for biology · 2024Article
- Metabolic engineering of a stable haploid strain derived from lignocellulosic inhibitor tolerant Saccharomyces cerevisiae natural isolate YB-2625.Biotechnology for biofuels and bioproducts · 2023Article
- Whole genome sequencing of Canadian Saccharomyces cerevisiae strains isolated from spontaneous wine fermentations reveals a new Pacific West Coast Wine clade.G3 (Bethesda, Md.) · 2023Article
- Yeast population dynamics in Brazilian bioethanol production.G3 (Bethesda, Md.) · 2023Article
- Physiology of Saccharomyces cerevisiae during growth on industrial sugar cane molasses can be reproduced in a tailor-made defined synthetic medium.Scientific reports · 2023Article
- Microcystin-Detoxifying RecombinantMicroorganisms · 2023Article
- Saccharomyces cerevisiae employs complex regulation strategies to tolerate low pH stress during ethanol production.Microbial cell factories · 2022Article
- Copy number variants impact phenotype-genotype relationships for adaptation of industrial yeast Saccharomyces cerevisiae.Applied microbiology and biotechnology · 2022Article
- Blocking Mitophagy Does Not Significantly Improve Fuel Ethanol Production in Bioethanol Yeast Saccharomyces cerevisiae.Applied and environmental microbiology · 2022Article
- QTL mapping of a Brazilian bioethanol strain links the cell wall protein-encoding gene GAS1 to low pH tolerance in S. cerevisiae.Biotechnology for biofuels · 2021Article
- Reasons for 2-furaldehyde and 5-hydroxymethyl-2-furaldehyde resistance in Saccharomyces cerevisiae: current state of knowledge and perspectives for further improvements.Applied microbiology and biotechnology · 2021Review
46 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 5 institutions in 2 countries.
Funding
Abstract
Bioethanol is a biofuel produced mainly from the fermentation of carbohydrates derived from agricultural feedstocks by the yeast Saccharomyces cerevisiae. One of the most widely adopted strains is PE-2, a heterothallic diploid naturally adapted to the sugar cane fermentation process used in Brazil. Here we report the molecular genetic analysis of a PE-2 derived diploid (JAY270), and the complete genome sequence of a haploid derivative (JAY291). The JAY270 genome is highly heterozygous (approximately 2 SNPs/kb) and has several structural polymorphisms between homologous chromosomes. These chromosomal rearrangements are confined to the peripheral regions of the chromosomes, with breakpoints within repetitive DNA sequences. Despite its complex karyotype, this diploid, when sporulated, had a high frequency of viable spores. Hybrid diploids formed by outcrossing with the laboratory strain S288c also displayed good spore viability. Thus, the rearrangements that exist near the ends of chromosomes do not impair meiosis, as they do not span regions that contain essential genes. This observation is consistent with a model in which the peripheral regions of chromosomes represent plastic domains of the genome that are free to recombine ectopically and experiment with alternative structures. We also explored features of the JAY270 and JAY291 genomes that help explain their high adaptation to industrial environments, exhibiting desirable phenotypes such as high ethanol and cell mass production and high temperature and oxidative stress tolerance. The genomic manipulation of such strains could enable the creation of a new generation of industrial organisms, ideally suited for use as delivery vehicles for future bioenergy technologies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.