ArticleThe journal of physical chemistry. A2009
Generalized indirect covariance NMR formalism for establishment of multidimensional spin correlations.
Article in The journal of physical chemistry. A, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Minimizing Pervasive Artifacts in 4D Covariance Maps for Protein Side Chain NMR Assignments.The journal of physical chemistry. A · 2021Article
- Non-Uniform and Absolute Minimal Sampling for High-Throughput Multidimensional NMR Applications.Chemistry (Weinheim an der Bergstrasse, Germany) · 2018Review
- Covariance nuclear magnetic resonance methods for obtaining protein assignments and novel correlations.Concepts in magnetic resonance. Part A, Bridging education and research · 2017Article
- Effortless assignment with 4D covariance sequential correlation maps.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2015Article
- Assignment of methyl NMR resonances of a 52 kDa protein with residue-specific 4D correlation maps.Journal of biomolecular NMR · 2015Article
- Nonuniform sampling and non-Fourier signal processing methods in multidimensional NMR.Progress in nuclear magnetic resonance spectroscopy · 2014Review
- Facilitated assignment of large protein NMR signals with covariance sequential spectra using spectral derivatives.Journal of the American Chemical Society · 2014Article
- The use of 1H-31P GHMBC and covariance NMR to unambiguously determine phosphate ester linkages in complex polysaccharide mixtures.Journal of biomolecular NMR · 2011Article
- A covariance NMR toolbox for MATLAB and OCTAVE.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2011Article
- A practical implementation of cross-spectrum in protein backbone resonance assignment.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2010Article
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2 authors.
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Abstract
Multidimensional nuclear magnetic resonance (NMR) experiments measure spin-spin correlations, which provide important information about bond connectivities and molecular structure. However, direct observation of certain kinds of correlations can be very time-consuming due to limitations in sensitivity and resolution. Covariance NMR derives correlations between spins via the calculation of a (symmetric) covariance matrix, from which a matrix-square root produces a spectrum with enhanced resolution. Recently, the covariance concept has been adopted to the reconstruction of nonsymmetric spectra from pairs of 2D spectra that have a frequency dimension in common. Since the unsymmetric covariance NMR procedure lacks the matrix-square root step, it does not suppress relay effects and thereby may generate false positive signals due to chemical shift degeneracy. A generalized covariance formalism is presented here that embeds unsymmetric covariance processing within the context of the regular covariance transform. It permits the construction of unsymmetric covariance NMR spectra subjected to arbitrary matrix functions, such as the square root, with improved spectral properties. This formalism extends the domain of covariance NMR to include the reconstruction of nonsymmetric NMR spectra at resolutions or sensitivities that are superior to the ones achievable by direct measurements.
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