ArticleThe Annals of otology, rhinology, and laryngology2009
Locus for familial migrainous vertigo disease maps to chromosome 5q35.
Article in The Annals of otology, rhinology, and laryngology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Vestibular migraine treatment: a comprehensive practical review.Brain : a journal of neurology · 2022Pooled it
- Systematic Review of Prevalence Studies and Familial Aggregation in Vestibular Migraine.Frontiers in genetics · 2020Pooled it
- Association of TRPM7 gene mutation with familial vestibular migraine.Neurogenetics · 2026Article
- A genome-wide association study identifies novel loci of vertigo in an Asian population-based cohort.Communications biology · 2024Article
- Case Series: Vestibular Migraines in Fragile X Premutation Carriers.Journal of clinical medicine · 2024Article
- Disorientation effects, circulating small ribonucleic acid, and genetic susceptibility on static postural stability.Heliyon · 2023Article
- Vestibular migraine: the chameleon in vestibular disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Review
- Evolution of migraine vertigo in overlapping syndrome with Ménière's disease: prognostic role of instrumental examination.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2021Article
- Genetics and the Individualized Therapy of Vestibular Disorders.Frontiers in neurology · 2021Review
- Article
- Association Between Migraine and Benign Paroxysmal Positional Vertigo Among Adults in South Korea.JAMA otolaryngology-- head & neck surgery · 2019Article
- Current Treatment Options: Vestibular Migraine.Current treatment options in neurology · 2017Review
- Meniere's Disease and Vestibular Migraine: Updates and Review of the Literature.Journal of clinical medicine research · 2017Review
- Vestibular Migraine: Clinical Challenges and Opportunities for Multidisciplinarity.Behavioural neurology · 2016Review
- Pediatric migraine variants: a review of epidemiology, diagnosis, treatment, and outcome.Current neurology and neuroscience reports · 2015Review
- New insights into pathophysiology of vestibular migraine.Frontiers in neurology · 2015Review
- Vertigo as a migraine phenomenon.Current neurology and neuroscience reports · 2013Review
- Genetics of recurrent vertigo and vestibular disorders.Current genomics · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
objectivesMigrainous vertigo (episodic vertigo associated with migraine) is sometimes inherited as an autosomal dominant trait. However, neither disease genes nor loci that might be responsible have been reported. We sought to map the genetic locus for familial migrainous vertigo in a 4-generation family and to define the progression of disease in this family.
methodsWe studied 23 members in a family in whom migrainous vertigo was inherited as an autosomal dominant trait. Clinical information obtained included case histories and results of otolaryngological, neurologic, audiometric, and imaging evaluations. Genome-wide linkage analysis was performed with Affymetrix Genechip Human Mapping 10K microarrays. Genotyping of family members' DNA with microsatellite markers was used to further assess candidate loci identified from the whole-genome scan.
resultsOf 23 family members, 10 suffered from migrainous vertigo beginning after 35 years of age. Migraine headaches usually preceded the onset of vertigo by 15 to 20 years. Longitudinal audiometric studies over 12 years showed stable, high-frequency sensorineural hearing loss consistent with presbycusis. Low-frequency or fluctuating hearing loss was not observed. The results of vestibular testing and imaging studies were unremarkable. Genetic analysis defined a 12.0 MB interval on chromosome 5q35 between loci rs244895 and D5S2073 that contained the disease gene (logarithm of odds score, 4.21).
conclusionsWe report the first locus for familial migrainous vertigo, which mapped to 5q35.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.