ArticleInternational journal of cancer2010
Trimodal age-specific incidence patterns for Burkitt lymphoma in the United States, 1973-2005.
Article in International journal of cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 72 citations in OpenAlex.
- Burkitt lymphoma: current understanding, unmet needs, and research directions.Blood advances · 2026Review
- Burkitt Lymphoma-A Guide to Biological Features, Diagnosis and Differential Diagnosis.Cancers · 2026Review
- Global Patterns, Temporal Trends, and Potential Non-Infectious Risk Factors for Burkitt Lymphoma from 1990 to 2021.Blood and lymphatic cancer : targets and therapy · 2026Article
- Case Report: Glofitamab in the treatment of a patient with central nervous system-involved Burkitt lymphoma.Frontiers in oncology · 2026Article
- Navigating Rare Presentations: Recurrent Burkitt Lymphoma Presenting as a Jejunal Mass.Clinical case reports · 2025Article
- Article
- Genomic landscape of virus-associated cancers.Nature communications · 2025Article
- Patterns of incident Burkitt lymphoma during the HIV epidemic among the Black African and White population in South Africa.British journal of cancer · 2025Article
- Fifteen Years of Non-Hodgkin Lymphoma in an Indonesian National Referral Hospital: Epidemiologic Trends and Diagnostic Challenges.JCO global oncology · 2024Article
- The Treatment of Burkitt Lymphoma With the Berlin-Frankfurt-Münster Protocol With Rituximab and Consolidative Autologous Transplantation.The oncologist · 2024Article
- Evolving Trends and Burden of Inflammatory Bowel Disease in Asia, 1990-2019: A Comprehensive Analysis Based on the Global Burden of Disease Study.Journal of epidemiology and global health · 2023Article
- Burkitt Lymphoma Presenting as Ileocolic Intussusception in an Adult.Open journal of blood diseases · 2023Article
- Incidence of Burkitt lymphoma in the United States during 2000 to 2019.International journal of cancer · 2023Article
- Article
- The burden of epilepsy in the People's Republic of China from 1990 to 2019: epidemiological trends and comparison with the global burden of epilepsy.Frontiers in neurology · 2023Article
- Epstein-Barr virus and Burkitt's lymphoma. Associations in Iraqi Kurdistan and twenty-two countries assessed in the International Incidence of Childhood Cancer.Infectious agents and cancer · 2022Article
- Improved survival of Burkitt lymphoma/leukemia patients: observations from Poland, 1999-2020.Annals of hematology · 2022Article
- Review
- Interplay between Epstein-Barr virus infection and environmental xenobiotic exposure in cancer.Infectious agents and cancer · 2021Review
- Epidemiology of adult and pediatric Burkitt lymphoma in Canada: sequelae of the HIV epidemic.Current oncology (Toronto, Ont.) · 2020Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Burkitt lymphoma (BL) is a unique B-cell non-Hodgkin lymphoma with 3 established clinical-epidemiological variants: endemic, sporadic and AIDS-related BL. BL variants show characteristic dysregulation of MYC gene, but the causes of MYC dysregulation or BL arising at different ages are poorly understood. Therefore, we examined population-based BL incidence patterns in the United States to determine age-related risk. BL case and population data were obtained from the NCI's Surveillance, Epidemiology and End Results Databases (1973-2005). Standard cross-sectional age-standardized and age-specific incidence rates were stratified by sex and race and supplemented with age-period-cohort models. We analyzed 3,058 BL cases diagnosed during 1,160,300,297 person-years of observation. Age-standardized incidence rates rose 6.8% per year (95% CI 4.5-9.1) for males and 7.1% (95% CI 3.2-11.1) for females during the study period. The rate among males was 3.2 times that among females, and among Whites 1.3 times that among Blacks. Male-to-female incidence rate ratios did not differ by race, but were 4.2 for pediatric (0-19 years), 4.1 for adult (20-59 years) and 2.0 for geriatric (> or = 60 years) BL. Cross-sectional age-specific rates showed 2 separate peaks among males and females, near ages 10 and 75 years, and a 3rd peak near age 40 years among males. The tri/bimodal incidence pattern was present in sensitivity analyses excluding registries with many HIV/AIDS cases and in period-specific, cohort-specific analyses. To our knowledge, tri/bimodal incidence patterns have not previously been reported for BL. Trimodal/bimodal BL suggests heterogeneity in etiology or biology of BL diagnosed at different ages in males and females.
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