ReviewCellular and molecular life sciences : CMLS2009
The exercising heart at altitude.
Review in Cellular and molecular life sciences : CMLS, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Sildenafil does not improve performance in 16.1 km cycle exercise time-trial in acute hypoxia.PloS one · 2019Trial
- Effect of Hypoxic Exercise with Different Oxygen Concentrations on Metabolic Outcomes in Obesity: A Systematic Review and Network Meta-Analysis.Life (Basel, Switzerland) · 2026Review
- Hypoxia and Tissue Regeneration: Adaptive Mechanisms and Therapeutic Opportunities.International journal of molecular sciences · 2025Review
- Physiological responses of children with surgically corrected congenital heart disease during high-altitude trekking: an exploratory observational study.Frontiers in pediatrics · 2025Article
- Article
- Acute Exercise with Moderate Hypoxia Reduces Arterial Oxygen Saturation and Cerebral Oxygenation without Affecting Hemodynamics in Physically Active Males.International journal of environmental research and public health · 2022Article
- Cardiovascular management following hypoxic-ischemic encephalopathy in North America: need for physiologic consideration.Pediatric research · 2021Article
- Post-exercise cardiac autonomic and cardiovascular responses to heart rate-matched and work rate-matched hypoxic exercise.European journal of applied physiology · 2021Article
- Systolic and Diastolic Functions After a Brief Acute Bout of Mild Exercise in Normobaric Hypoxia.Frontiers in physiology · 2021Article
- Delayed parasympathetic reactivation and sympathetic withdrawal following maximal cardiopulmonary exercise testing (CPET) in hypoxia.European journal of applied physiology · 2018Article
- Oxidative protein modification alters proteostasis under acute hypobaric hypoxia in skeletal muscles: a comprehensive in vivo study.Cell stress & chaperones · 2017Article
- Increased PIO2 at Exhaustion in Hypoxia Enhances Muscle Activation and Swiftly Relieves Fatigue: A Placebo or a PIO2 Dependent Effect?Frontiers in physiology · 2016Article
- Impaired myocardial function does not explain reduced left ventricular filling and stroke volume at rest or during exercise at high altitude.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Cerebral oxygenation during the Richalet hypoxia sensitivity test and cycling time-trial performance in severe hypoxia.European journal of applied physiology · 2014Article
- Compensatory vasodilatation during hypoxic exercise: mechanisms responsible for matching oxygen supply to demand.The Journal of physiology · 2012Review
- Usefulness of combining intermittent hypoxia and physical exercise in the treatment of obesity.Journal of physiology and biochemistry · 2012Review
- Phenotypic plasticity and genetic adaptation to high-altitude hypoxia in vertebrates.The Journal of experimental biology · 2010Review
- High-altitude exposure and ischemic stroke: pathophysiological mechanisms and current perspectives.Frontiers in neurologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maximal cardiac output is reduced in severe acute hypoxia but also in chronic hypoxia by mechanisms that remain poorly understood. In theory, the reduction of maximal cardiac output could result from: (1) a regulatory response from the central nervous system, (2) reduction of maximal pumping capacity of the heart due to insufficient coronary oxygen delivery prior to the achievement of the normoxic maximal cardiac output, or (3) reduced central command. In this review, we focus on the effects that acute and chronic hypoxia have on the pumping capacity of the heart, particularly on myocardial contractility and the molecular responses elicited by acute and chronic hypoxia in the cardiac myocytes. Special emphasis is put on the cardioprotective effects of chronic hypoxia.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.