ArticleDose-response : a publication of International Hormesis Society2009
Turnover modeling of non-esterified fatty acids in rats after multiple intravenous infusions of nicotinic acid.
Article in Dose-response : a publication of International Hormesis Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Modeling of free fatty acid dynamics: insulin and nicotinic acid resistance under acute and chronic treatments.Journal of pharmacokinetics and pharmacodynamics · 2017Pooled it
- Frequency-Domain Response Analysis for Quantitative Systems Pharmacology Models.CPT: pharmacometrics & systems pharmacology · 2017Article
- Pattern Recognition in Pharmacodynamic Data Analysis.The AAPS journal · 2016Review
- Joint feedback analysis modeling of nonesterified fatty acids in obese Zucker rats and normal Sprague-Dawley rats after different routes of administration of nicotinic acid.Journal of pharmaceutical sciences · 2014Article
- Feedback modeling of non-esterified fatty acids in obese Zucker rats after nicotinic acid infusions.Journal of pharmacokinetics and pharmacodynamics · 2013Article
- Challenges of a mechanistic feedback model describing nicotinic acid-induced changes in non-esterified fatty acids in rats.Journal of pharmacokinetics and pharmacodynamics · 2013Article
- Dynamic modeling of methylprednisolone effects on body weight and glucose regulation in rats.Journal of pharmacokinetics and pharmacodynamics · 2011Article
- Feedback modeling of non-esterified fatty acids in rats after nicotinic acid infusions.Journal of pharmacokinetics and pharmacodynamics · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this investigation was to use a pharmacokinetic (PK)/pharmacodynamic (PD) approach to describe and evaluate a PK model of nicotinic acid (NiAc) in guinea pigs and a PD feedback model of changes in non-esterified fatty acid (NEFA) concentrations in rats following multiple intravenous infusions of NiAc at different rates and durations of inhouse and literature (NEFA after extravascular NiAc dosing) data. Serial arterial blood samples were taken for evaluation of NiAc exposure in guinea pigs and NEFA in rats. The biophase kinetics of NiAc was assumed to impact on NEFA turnover with feedback incorporated via an inhibitory moderator compartment. The response acted linearly on the production of moderator, which then acted inversely on the turnover rate of response. The potency, expressed as the amount of NiAc in the biophase causing a 50 % inhibitory effect (ID(50)), was 6.5 nmol +/- 31 % and the half-life of response (t(1/2, kout)) 2 min +/- 18 %. The half-life of tolerance (t(1/2, ktol)) was 9 min +/- 27 %. The model can be used to provide information about factors that determine the time course of NEFA response following different rates and routes of administration of NiAc or NiAc analogues.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.