ReviewCurrent opinion in cardiology2009
The role of low endothelial shear stress in the conversion of atherosclerotic lesions from stable to unstable plaque.
Review in Current opinion in cardiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 123 citations in OpenAlex.
- Association of atherosclerotic cardiovascular disease risk stratification with carotid wall shear stress as measured by vector flow mapping: a study of a Chinese population.Quantitative imaging in medicine and surgery · 2026Article
- Cytokeratin-1 is essential for the detection of laminar shear stress in endothelial cells.Animal cells and systems · 2025Article
- High-Frequency, 2-mm-Diameter Forward-Viewing 2-D Array for 3-D Intracoronary Blood Flow Imaging.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2024Article
- Carotid Arterial Compliance during Different Intensities of Submaximal Endurance Exercise.Journal of clinical medicine · 2024Article
- Dynamic Coronary Blood Flow Velocity and Wall Shear Stress Estimation Using Ultrasound in an Ex Vivo Porcine Heart.Cardiovascular engineering and technology · 2024Article
- Exercise-based cardiac rehabilitation in stable angina pectoris: a narrative review on current evidence and underlying physiological mechanisms.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2024Review
- The pathophysiology and management of depression in cardiac surgery patients.Frontiers in psychiatry · 2023Review
- Increased Proximal Wall Shear Stress of Basilar Artery Plaques Associated with Ruptured Fibrous Cap.Brain sciences · 2022Article
- Tenascin-C as a noninvasive biomarker of coronary artery disease.Molecular biology reports · 2022Article
- Differences in Blood Flow Patterns and Endothelial Shear Stress at the Carotid Artery Using Different Exercise Modalities and Intensities.Frontiers in physiology · 2022Article
- An Interpretable Machine Learning Model to Classify Coronary Bifurcation Lesions.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2021Article
- Comparison of half-turned truncal switch and conventional operations.Interactive cardiovascular and thoracic surgery · 2021Article
- Non-invasive characterization of complex coronary lesions.Scientific reports · 2021Article
- Impact of proximal and distal cuff inflation on brachial artery endothelial function in healthy individuals.European journal of applied physiology · 2021Article
- Short Communication: Carotid Artery Plaque Burden in HIV Is Associated with Soluble Mediators and Monocytes.AIDS research and human retroviruses · 2020Article
- Calcium-Binding Protein S100A4 Is Upregulated in Carotid Atherosclerotic Plaques and Contributes to Expansive Remodeling.Journal of the American Heart Association · 2020Article
- Macrophage accumulation within coronary arterial wall in diabetic patients with acute coronary syndrome: a study with in-vivo intravascular imaging modalities.Cardiovascular diabetology · 2020Article
- Multidirectional wall shear stress promotes advanced coronary plaque development: comparing five shear stress metrics.Cardiovascular research · 2020Article
- Biomechanical Forces and Atherosclerosis: From Mechanism to Diagnosis and Treatment.Current cardiology reviews · 2020Review
- Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
purpose of reviewLocal hemodynamic factors are major determinants of the natural history of individual atherosclerotic plaque progression in coronary arteries. The purpose of this review is to summarize the role of low endothelial shear stress (ESS) in the transition of early, stable plaques to high-risk atherosclerotic lesions. RECENT
findingsLow ESS regulates multiple pathways within the atherosclerotic lesion, resulting in intense vascular inflammation, progressive lipid accumulation, and formation and expansion of a necrotic core. Upregulation of matrix-degrading proteases promotes thinning of the fibrous cap, severe internal elastic lamina fragmentation, and extracellular matrix remodeling. In the setting of plaque-induced changes of the local ESS, coronary regions persistently exposed to very low ESS develop excessive expansive remodeling, which further exacerbates the proinflammatory low ESS stimulus. Recent studies suggest that the effect of recognized cardioprotective medications may be mediated by attenuation of the proinflammatory effect of the low ESS environment in which a plaque develops. SUMMARY: Low ESS determines the severity of vascular inflammation, the status of the extracellular matrix, and the nature of wall remodeling, all of which synergistically promote the transition of stable lesions to thin cap fibroatheromata that may rupture with subsequent formation of an occlusive thrombus and result in an acute coronary syndrome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.