ArticleThe Journal of clinical endocrinology and metabolism2009
Influence of age and obesity on serum estradiol, estrone, and sex hormone binding globulin concentrations following oral estrogen administration in postmenopausal women.
Article in The Journal of clinical endocrinology and metabolism, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 53 citations in OpenAlex.
- Sex steroid hormones and subclinical atherosclerosis progression in postmenopausal women.European journal of endocrinology · 2025Trial
- Determinants of attained estradiol levels in response to oral estradiol plus progesterone therapy.Climacteric : the journal of the International Menopause Society · 2021Trial
- Factors Associated With Serum Estradiol Levels Among Postmenopausal Women Using Hormone Therapy.Obstetrics and gynecology · 2020Trial
- Weight loss increases follicle stimulating hormone in overweight postmenopausal women [corrected].Obesity (Silver Spring, Md.) · 2015Trial
- Association between diabetes and tinnitus traits in the UK Biobank: a population-based cohort study.Acta diabetologica · 2026Article
- Associations of sex hormone ratios with metabolic syndrome and inflammation in US adult men and women.Frontiers in endocrinology · 2024Article
- Estradiol and Estrone Have Different Biological Functions to Induce NF-κB-Driven Inflammation, EMT and Stemness in ER+ Cancer Cells.International journal of molecular sciences · 2023Article
- Concentrations of endogenous sex steroid hormones and SHBG in healthy postmenopausal women.The Journal of steroid biochemistry and molecular biology · 2022Article
- The Influence of Body Mass Index on the Histopathology and Outcomes of Patients Diagnosed with Atypical Breast Lesions.Annals of surgical oncology · 2022Article
- The Interplay of Race/Ethnicity and Obesity on the Incidence of Venous Thromboembolism.American journal of preventive medicine · 2022Article
- Associations of body shape phenotypes with sex steroids and their binding proteins in the UK Biobank cohort.Scientific reports · 2022Article
- Oral estrogen leads to falsely low concentrations of estradiol in a common immunoassay.Endocrine connections · 2022Article
- Gender Differences in Obesity-Related Cancers.Current obesity reports · 2021Review
- Conjugated equine estrogen used in postmenopausal women associated with a higher risk of stroke than estradiol.Scientific reports · 2021Article
- Clinical impact of estradiol/testosterone ratio in patients with acute ischemic stroke.BMC neurology · 2021Article
- Bibliometrics Analysis of the Research Status and Trends of the Association Between Depression and Insulin From 2010 to 2020.Frontiers in psychiatry · 2021Review
- Optimal body mass index for minimizing the risk for osteoporosis and type 2 diabetes.The Korean journal of internal medicine · 2020Article
- Association between the Geriatric Nutritional Risk Index, bone mineral density and osteoporosis in type 2 diabetes patients.Journal of diabetes investigation · 2020Article
- Review
- Circulating zearalenone and its metabolites differ in women due to body mass index and food intake.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveHormone therapy (HT) increases the risk of venous thrombosis and stroke. Risk of venous thrombosis and stroke is higher in older, overweight, and obese women using HT. However, the impact of age and obesity on estrogen concentrations among HT users is not well defined.
methodWe measured serum levels of estrone, total and free estradiol, and SHBG in 180 postmenopausal women participating in the Estrogen in the Prevention of Atherosclerosis Trial (EPAT), 91 receiving estradiol therapy (ET) and 89 taking placebo, every 6 months over 2 yr. Mean on-trial levels of estrogens and SHBG were compared across age, body mass index (BMI), and waist to hip ratio categories among ET users and placebo separately.
resultsAmong the ET users, total (P = 0.01) and free estradiol (P = 0.002) were significantly directly associated with BMI adjusted for age. SHBG was inversely related to waist to hip ratio adjusted for age (P = 0.005). Age was not associated with any of the estrogen or SHBG concentrations in ET or placebo groups. BMI was positively associated with estrone concentrations among older but not younger ET users (P for interaction = 0.03).
conclusionOverweight and obese women using ET attain greater concentrations of estrogen compared to women with normal BMI, whereas ET users with abdominal obesity attain lower SHBG levels. Obese older women using ET have the highest concentration of estrone. It may be useful to consider age and obesity when prescribing HT to minimize the risk of venous thrombosis or stroke in postmenopausal women. Further research regarding relationships among circulating hormone levels and risk for these conditions is required to substantiate this conclusion.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.