ArticleEvidence-based complementary and alternative medicine : eCAM2011
Schwann Cell Migration Induced by Earthworm Extract via Activation of PAs and MMP2/9 Mediated through ERK1/2 and p38.
Article in Evidence-based complementary and alternative medicine : eCAM, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
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- An Integrated Strategy of Chemical Fingerprint and Network Pharmacology for the Discovery of Efficacy-Related Q-Markers ofInternational journal of analytical chemistry · 2022Article
- Bioactive Earthworm Peptides Produced by Novel Protease-ProducingFrontiers in microbiology · 2022Article
- The transcriptome of anterior regeneration in earthworm Eudrilus eugeniae.Molecular biology reports · 2021Article
- Effects of PIN on Osteoblast Differentiation and Matrix Mineralization through Runt-Related Transcription Factor.International journal of molecular sciences · 2020Article
- 7-HYB, a Phenolic Compound Isolated fromInternational journal of molecular sciences · 2020Article
- TMARg, a Novel Anthraquinone Isolated fromInternational journal of molecular sciences · 2020Article
- A Phytochemical Constituent, (E)-Methyl-Cinnamate Isolated fromInternational journal of molecular sciences · 2020Article
- The Effects of Leukocyte-Platelet Rich Fibrin (L-PRF) on Suppression of the Expressions of the Pro-Inflammatory Cytokines, and Proliferation of Schwann Cell, and Neurotrophic Factors.Scientific reports · 2020Article
- Suppression of Cell Growth, Migration and Drug Resistance by Ethanolic Extract of Antrodia cinnamomea in Human Lung Cancer A549 Cells and C57BL/6J Allograft Tumor Model.International journal of molecular sciences · 2018Article
- Study of analgesic effect of earthworm extract.Bioscience reports · 2018Article
- Miconazole protects blood vessels from MMP9-dependent rupture and hemorrhage.Disease models & mechanisms · 2017Article
- IVIG inhibits TNF-α-induced MMP9 expression and activity in monocytes by suppressing NF-κB and P38 MAPK activation.International journal of clinical and experimental pathology · 2015Article
- Earthworm (Pheretima aspergillum) extract stimulates osteoblast activity and inhibits osteoclast differentiation.BMC complementary and alternative medicine · 2014Article
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- Evaluating the bone tissue regeneration capability of the Chinese herbal decoction Danggui Buxue Tang from a molecular biology perspective.BioMed research international · 2014Article
- Origin of innate immune responses: revelation of food and medicinal applications.Journal of traditional and complementary medicine · 2013Review
- Dilong: food for thought and medicine.Journal of traditional and complementary medicine · 2012Article
- Effect of oral administration of Pheretima aspergillum (earthworm) in rats with cerebral infarction induced by middle-cerebral artery occlusion.African journal of traditional, complementary, and alternative medicines : AJTCAM · 2012Article
- Earthworms dilong: ancient, inexpensive, noncontroversial models may help clarify approaches to integrated medicine emphasizing neuroimmune systems.Evidence-based complementary and alternative medicine : eCAM · 2012Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The earthworm, which has stasis removal and wound-healing functions, is a widely used Chinese herbal medicine in China. Schwann cell migration is critical for the regeneration of injured nerves. Schwann cells provide an essentially supportive activity for neuron regeneration. However, the molecular migration mechanisms induced by earthworms in Schwann cells remain unclear. Here, we investigate the roles of MAPK (ERK1/2, JNK and p38) pathways for earthworm-induced matrix-degrading proteolytic enzyme (PAs and MMP2/9) production in Schwann cells. Moreover, earthworm induced phosphorylation of ERK1/2 and p38, but not JNK, activate the downstream signaling expression of PAs and MMPs in a time-dependent manner. Earthworm-stimulated ERK1/2 and p38 phosphorylation was attenuated by pretreatment with U0126 and SB203580, resulting in migration and uPA-related signal pathway inhibition. The results were confirmed using small interfering ERK1/2 and p38 RNA. These results demonstrated that earthworms can stimulate Schwann cell migration and up-regulate PAs and MMP2/9 expression mediated through the MAPK pathways, ERK1/2 and p38. Taken together, our data suggests the MAPKs (ERK1/2, p38)-, PAs (uPA, tPA)-, MMP (MMP2, MMP9) signaling pathway of Schwann cells regulated by earthworms might play a major role in Schwann cell migration and nerve regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.