ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2009
Effects of chronic overload on muscle hypertrophy and mTOR signaling in young adult and aged rats.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Loaded inter-set stretch may selectively enhance muscular adaptations of the plantar flexors.PloS one · 2022Trial
- Efficacy of whey protein supplementation on resistance exercise-induced changes in lean mass, muscle strength, and physical function in mobility-limited older adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2013Trial
- Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions.Physiological reviews · 2023Review
- Does the blunted stimulation of skeletal muscle protein synthesis by aging in response to mechanical load result from impaired ribosome biogenesis?Frontiers in aging · 2023Review
- Physiopathology of Lifestyle Interventions in Non-Alcoholic Fatty Liver Disease (NAFLD).Nutrients · 2020Review
- Skeletal Muscle Recovery from Disuse Atrophy: Protein Turnover Signaling and Strategies for Accelerating Muscle Regrowth.International journal of molecular sciences · 2020Review
- Do the anatomical and physiological properties of a muscle determine its adaptive response to different loading protocols?Physiological reports · 2020Article
- Muscle hypertrophy in hypoxia with inflammation is controlled by bromodomain and extra-terminal domain proteins.Scientific reports · 2017Article
- mTOR as a Key Regulator in Maintaining Skeletal Muscle Mass.Frontiers in physiology · 2017Review
- Blunted hypertrophic response in aged skeletal muscle is associated with decreased ribosome biogenesis.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Effect of age on basal muscle protein synthesis and mTORC1 signaling in a large cohort of young and older men and women.Experimental gerontology · 2015Article
- Regrowth after skeletal muscle atrophy is impaired in aged rats, despite similar responses in signaling pathways.Experimental gerontology · 2015Article
- Late-life enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle.Age (Dordrecht, Netherlands) · 2013Article
- Fish oil positively regulates anabolic signalling alongside an increase in whole-body gluconeogenesis in ageing skeletal muscle.European journal of nutrition · 2013Article
- Atrogin-1, MuRF-1, and sarcopenia.Endocrine · 2013Review
- Increased ceramide content and NFκB signaling may contribute to the attenuation of anabolic signaling after resistance exercise in aged males.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
- Akt (protein kinase B) isoform phosphorylation and signaling downstream of mTOR (mammalian target of rapamycin) in denervated atrophic and hypertrophic mouse skeletal muscle.Journal of molecular signaling · 2012Article
- The effect of physiological stimuli on sarcopenia; impact of Notch and Wnt signaling on impaired aged skeletal muscle repair.International journal of biological sciences · 2012Review
- Usefulness of preclinical models for assessing the efficacy of late-life interventions for sarcopenia.The journals of gerontology. Series A, Biological sciences and medical sciences · 2012Review
- Lipogenic regulators are elevated with age and chronic overload in rat skeletal muscle.Acta physiologica (Oxford, England) · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
We examined the effect of 28 days of overload on mammalian target of rapamycin (mTOR) and extracellular signal-regulated kinase (ERK) signaling in young adult (Y; 6-month old) and aged (O; 30-month old) Fischer 344 x Brown Norway rats subjected to bilateral synergist ablation (SA) of two thirds of the gastrocnemius muscle or sham surgery (CON). Although plantaris (PLA) muscle hypertrophy was attenuated by aging, mTOR phosphorylation was 44% and 35% greater in Y SA and O SA compared with CON (p = .038). Ribosomal protein S6 phosphorylation was 114% and 24% higher in Y SA and O SA compared with CON (p = .009). Eukaryotic initiation factor 2Bepsilon phosphorylation was 33% and 9% higher in Y SA and O SA compared with CON (p = .04). Translational signaling in young adult and aged plantaris muscle is equally responsive to chronic overload.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.