ArticleThe Journal of pharmacology and experimental therapeutics2010
Erythropoietic response to endogenous erythropoietin in premature very low birth weight infants.
Article in The Journal of pharmacology and experimental therapeutics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 44 citations in OpenAlex.
- A randomized, masked study of weekly erythropoietin dosing in preterm infants.The Journal of pediatrics · 2012Trial
- Very low birth weight infants qualifying for a 'late' erythrocyte transfusion: does giving darbepoetin along with the transfusion counteract the transfusion's erythropoietic suppression?Journal of perinatology : official journal of the California Perinatal Association · 2011Trial
- Gestational age references and trajectory of fetal haemoglobin in relation to outcome in neonates born before 30 weeks of gestation: a single-centre retrospective cohort study in The Netherlands.EClinicalMedicine · 2026Article
- Neonatal clinical blood sampling led to major blood loss and was associated with bronchopulmonary dysplasia.Acta paediatrica (Oslo, Norway : 1992) · 2020Article
- Neonatal Umbilical Arterial Catheter Removal Is Accompanied by a Marked Decline in Phlebotomy Blood Loss.Neonatology · 2020Article
- Patterns of phlebotomy blood loss and transfusions in extremely low birth weight infants.Journal of perinatology : official journal of the California Perinatal Association · 2019Article
- Robust increases in erythropoietin production by the hypoxic fetus is a response to protect the brain and other vital organs.Pediatric research · 2018Review
- Jack Widness: the importance of connections.Pediatric research · 2018Article
- Antibodies to biotinylated red blood cells in adults and infants: improved detection, partial characterization, and dependence on red blood cell-biotin dose.Transfusion · 2017Article
- Estimation of adult and neonatal RBC lifespans in anemic neonates using RBCs labeled at several discrete biotin densities.Pediatric research · 2017Article
- Reticulocyte Hemoglobin Content During the First Month of Life in Critically Ill Very Low Birth Weight Neonates Differs From Term Infants, Children, and Adults.Journal of clinical laboratory analysis · 2016Article
- A Mass Balance-Based Semiparametric Approach to Evaluate Neonatal Erythropoiesis.The AAPS journal · 2016Article
- A Method to Evaluate Fetal Erythropoiesis from Postnatal Survival of Fetal RBCs.The AAPS journal · 2015Article
- Why do four NICUs using identical RBC transfusion guidelines have different gestational age-adjusted RBC transfusion rates?Journal of perinatology : official journal of the California Perinatal Association · 2015Article
- Mathematical model of platelet turnover in thrombocytopenic and nonthrombocytopenic preterm neonates.American journal of physiology. Heart and circulatory physiology · 2015Article
- New and underutilized uses of umbilical cord blood in neonatal care.Maternal health, neonatology and perinatology · 2015Review
- Pharmacodynamically optimized erythropoietin treatment combined with phlebotomy reduction predicted to eliminate blood transfusions in selected preterm infants.Pediatric research · 2014Article
- Tracking donor RBC survival in premature infants: agreement of multiple populations of biotin-labeled RBCs with Kidd antigen-mismatched RBCs.Pediatric research · 2013Article
- Respective effects of phlebotomy losses and erythropoietin treatment on the need for blood transfusion in very premature infants.BMC pediatrics · 2013Article
- A mathematical modeling approach to quantify the role of phlebotomy losses and need for transfusions in neonatal anemia.Transfusion · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Despite the common occurrence of anemia in very low birth weight (VLBW) infants, the erythropoiesis and Hb production rates and their relationship to plasma erythropoietin (EPO) concentrations remain unknown in these subjects. To determine these quantities, all blood removed by phlebotomy and administered by red blood cell (RBC) transfusion over the first 30 days of life was recorded in 14 ventilated VLBW infants born at 24 to 28 weeks of gestation. Discarded blood from frequent clinically ordered laboratory blood samples was used to construct plasma EPO, Hb, and RBC concentration-time profiles for each infant. A pharmacodynamic Hb mass balance model that accounted for the dynamic hematological conditions experienced by these infants was simultaneously fitted to the plasma EPO, Hb, and RBC concentrations from each individual subject, while accounting for subject growth. Based on the model estimates, an average of 4.69 g of Hb was produced over the first 30 days of life, compared with 5.97 g removed by phlebotomies and 12.3 g administered by transfusions. These high transfusion amounts were consistent with a relatively short RBC life span and rapidly expanding blood volume with infant growth. The estimated mean body weight-scaled Hb production rate dropped nearly 3-fold after birth to 0.144 g/day x (kg)(3/4). Although only estimated in a subset of the subjects, the mean plasma EPO EC(50) of 28.5 mU/ml and maximal Hb production rate (E(max)) indicated that a severalfold increase in Hb production rate could be achieved with only a modest increase in plasma EPO concentrations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.