ArticleCirculation. Cardiovascular imaging2008
Myocardial alterations in senescent mice and effect of exercise training: a strain rate imaging study.
Article in Circulation. Cardiovascular imaging, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Young Mice Exhibit Increased Relative Ventricular Remodeling After AMI-A Longitudinal CMR Study.Aging cell · 2026Article
- Evaluating the effects of exercise and phellodendron amurense on cardiac function in a prostate cancer mouse model.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Small extracellular vesicles from young plasma reverse age-related functional declines by improving mitochondrial energy metabolism.Nature aging · 2024Article
- MG53 suppresses NF-κB activation to mitigate age-related heart failure.JCI insight · 2021Article
- Adipose tissue senescence is mediated by increased ATP content after a short-term high-fat diet exposure.Aging cell · 2021Article
- Cardiolipin content controls mitochondrial coupling and energetic efficiency in muscle.Science advances · 2021Article
- The Effect of Cardiogenic Factors on Cardiac Mesenchymal Cell Anti-Fibrogenic Paracrine Signaling and Therapeutic Performance.Theranostics · 2020Article
- Cardiac adenylyl cyclase overexpression precipitates and aggravates age-related myocardial dysfunction.Cardiovascular research · 2019Article
- Echocardiographic Strain Analysis for the Early Detection of Left Ventricular Systolic/Diastolic Dysfunction and Dyssynchrony in a Mouse Model of Physiological Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Intermittent Hypoxia Mimicking Sleep Apnea Increases Passive Stiffness of Myocardial Extracellular Matrix. A Multiscale Study.Frontiers in physiology · 2018Article
- Obligatory role for GPER in cardiovascular aging and disease.Science signaling · 2016Article
- The Role of Exercise in Cardiac Aging: From Physiology to Molecular Mechanisms.Circulation research · 2016Review
- Fatiguing exercise initiated later in life reduces incidence of fibrillation and improves sleep quality in Drosophila.Age (Dordrecht, Netherlands) · 2015Article
- Cardiac assessment in pediatric mice: strain analysis as a diagnostic measurement.Echocardiography (Mount Kisco, N.Y.) · 2014Article
- Myocardial extracellular volume fraction from T1 measurements in healthy volunteers and mice: relationship to aging and cardiac dimensions.JACC. Cardiovascular imaging · 2013Article
- Imaging of wall motion coupled with blood flow velocity in the heart and vessels in vivo: a feasibility study.Ultrasound in medicine & biology · 2011Article
- Echocardiography in Mice.Current protocols in mouse biology · 2011Article
- Drosophila models of cardiac disease.Progress in molecular biology and translational science · 2011Review
- Speckle-tracking 2-dimensional strain echocardiography: a new noninvasive imaging tool to evaluate acute rejection in cardiac transplantation.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2010Article
- Ventricular remodeling and function: insights using murine echocardiography.Journal of molecular and cellular cardiology · 2010Review
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Authors and funding
11 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundAging is accompanied by an alteration in myocardial contractility. However, its noninvasive detection is difficult. The effect of chronic exercise on this decrease is unknown. Murine models of senescence are increasingly used to test therapies in aging. We tested whether strain rate imaging detected left ventricular (LV) systolic dysfunction in aging mice and was able to assess a potential improvement after exercise. METHODS AND
resultsYoung (3 weeks), adult (2 to 3 months), and old (6 to 18 months) C57BL6 male mice underwent echocardiograms with strain rate imaging, either in sedentary conditions or before, 2 weeks and 4 weeks after chronic swimming. Hemodynamic parameters of LV function including maximal and end-systolic elastance were obtained before euthanizing. LV fibrosis was measured using Sirius red staining. Conventional echocardiography was unable to detect LV systolic dysfunction in old mice, whereas both systolic strain rate and load-independent hemodynamic parameters such as preload recruitable stroke work and end-systolic elastance were significantly decreased. Both strain rate and load-independent hemodynamic parameters normalized after 4 weeks of exercise. Both endocardial and epicardial fibrosis were increased in the LV of aging mice. Endocardial fibrosis decreased in exercised aged mice.
conclusionsStrain rate noninvasively detects LV systolic dysfunction associated with aging in mice, whereas conventional echocardiography does not. Chronic exercise normalizes LV systolic function and decreases fibrosis in old mice. Strain rate imaging in mice may be a useful tool to monitor the effect of new therapeutic strategies preventing the myocardial dysfunction associated with aging.
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