ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2009
Interstrain differences in the development of pyometra after estrogen treatment of rats.
Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- Vaginal Bleeding and an Intra-Abdominal Mass in a Sprague-Dawley Rat (Rattus norvegicus).Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- In vivo growth trajectories of regional brain volumes in the Wistar rat.Neurobiology of aging · 2025Article
- Clinical Assessment of Urinary Tract Damage during Sustained-Release Estrogen Supplementation in Mice.Comparative medicine · 2017Article
- Age-dependent regulation of obesity and Alzheimer-related outcomes by hormone therapy in female 3xTg-AD mice.PloS one · 2017Article
- Nonproliferative and proliferative lesions of the rat and mouse female reproductive system.Journal of toxicologic pathology · 2014Review
- Strain specific induction of pyometra and differences in immune responsiveness in mice exposed to 17α-ethinyl estradiol or the endocrine disrupting chemical bisphenol A.Reproductive toxicology (Elmsford, N.Y.) · 2012Article
- Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses.Endocrine reviews · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
This case report describes the unanticipated development of pyometra in Brown Norway rats after treatment with estrogen. Sprague Dawley and Brown Norway rats were ovariectomized and randomly assigned to treatment groups (subcutaneous implantation of either a capsule containing 20 mg 17beta-estradiol or an empty capsule, as a control). After irradiation of only the right eye, the rats were followed for several months in an attempt to determine the effects of estrogen on radiation cataractogenesis and investigate potential strain differences in this phenomenon. However, all Brown Norway rats that received estradiol treatment developed pyometra, whereas none the Sprague Dawley or control Brown Norway rats did. This case demonstrates the potential adverse effects of exogenous estrogen therapy, which are strain-specific in the rat. Caution should be taken when designing estrogen-related experiments involving Brown Norway rats and other potentially sensitive strains.
Indexed as
Identifiers
19807973PMC2755022W1538672759What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.