ArticleGenome biology2009
Draft genome sequence of the Daphnia pathogen Octosporea bayeri: insights into the gene content of a large microsporidian genome and a model for host-parasite interactions.
Article in Genome biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed, 76 citations in OpenAlex.
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- Bioinformatics analysis of the Microsporidia sp. MB genome: a malaria transmission-blocking symbiont of the Anopheles arabiensis mosquito.BMC genomics · 2024Article
- Near chromosome-level genome assembly of the microsporidium Hamiltosporidium tvaerminnensis.G3 (Bethesda, Md.) · 2023Article
- Comparative Genomics of Microsporidia.Experientia supplementum (2012) · 2022Article
- Genome and Evolutionary Analysis ofFrontiers in microbiology · 2021Article
- Complete genome of a unicellular parasite (Microbial genomics · 2020Article
- Microsporidia with Vertical Transmission Were Likely Shaped by Nonadaptive Processes.Genome biology and evolution · 2020Article
- Transposable element abundance correlates with mode of transmission in microsporidian parasites.Mobile DNA · 2020Article
- Article
- Origin and evolution of fungal HECT ubiquitin ligases.Scientific reports · 2018Article
- Fungal Genomes and Insights into the Evolution of the Kingdom.Microbiology spectrum · 2017Article
- Genome Analysis of Pseudoloma neurophilia: A Microsporidian Parasite of Zebrafish (Danio rerio).The Journal of eukaryotic microbiology · 2017Article
- Genome analysis and polar tube firing dynamics of mosquito-infecting microsporidia.Fungal genetics and biology : FG & B · 2015Article
- Contrasting host-pathogen interactions and genome evolution in two generalist and specialist microsporidian pathogens of mosquitoes.Nature communications · 2015Article
- Review
- Morphological and phylogenetic analysis of Nosema sp. HR (Microsporidia, Nosematidae): a new microsporidian pathogen of Histia rhodope Cramer (Lepidoptera, Zygaenidae).Parasitology research · 2015Article
- Identification, Diversity and Evolution of MITEs in the Genomes of Microsporidian Nosema Parasites.PloS one · 2015Article
- The Prediction and Validation of Small CDSs Expand the Gene Repertoire of the Smallest Known Eukaryotic Genomes.PloS one · 2015Article
- Microsporidian genomes harbor a diverse array of transposable elements that demonstrate an ancestry of horizontal exchange with metazoans.Genome biology and evolution · 2014Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundThe highly compacted 2.9-Mb genome of Encephalitozoon cuniculi placed the microsporidia in the spotlight, encoding a mere 2,000 proteins and a highly reduced suite of biochemical pathways. This extreme level of reduction is not universal across the microsporidia, with genomes known to vary up to sixfold in size, suggesting that some genomes may harbor a gene content that is not as reduced as that of Enc. cuniculi. In this study, we present an in-depth survey of the large genome of Octosporea bayeri, a pathogen of Daphnia magna, with an estimated genome size of 24 Mb, in order to shed light on the organization and content of a large microsporidian genome.
resultsUsing Illumina sequencing, 898 Mb of O. bayeri genome sequence was generated, resulting in 13.3 Mb of unique sequence. We annotated a total of 2,174 genes, of which 893 encodes proteins with assigned function. The gene density of the O. bayeri genome is very low on average, but also highly uneven, so gene-dense regions also occur. The data presented here suggest that the O. bayeri proteome is well represented in this analysis and is more complex that that of Enc. cuniculi. Functional annotation of O. bayeri proteins suggests that this species might be less biochemically dependent on its host for its metabolism than its more reduced relatives.
conclusionsThe combination of the data presented here, together with the imminent annotated genome of Daphnia magna, will provide a wealth of genetic and genomic tools to study host-parasite interactions in an interesting model for pathogenesis.
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