ArticleClinical and experimental immunology2010
Laser microdissection-based analysis of cytokine balance in the kidneys of patients with lupus nephritis.
Article in Clinical and experimental immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 121 citations in OpenAlex.
- Distinction Between Proliferative Lupus Nephritis and Membranous Lupus Nephritis Based on Inflammation, NETosis, and Glomerular Exostosin.International journal of molecular sciences · 2025Review
- Progranulin mediates the onset of pristane induced systemic lupus erythematosus.Advances in rheumatology (London, England) · 2024Article
- The Role of the Oxidative State and Innate Immunity Mediated by TLR7 and TLR9 in Lupus Nephritis.International journal of molecular sciences · 2023Review
- Cytokines in Systemic Lupus Erythematosus-Focus on TNF-α and IL-17.International journal of molecular sciences · 2023Review
- Decipher the Immunopathological Mechanisms and Set Up Potential Therapeutic Strategies for Patients with Lupus Nephritis.International journal of molecular sciences · 2023Review
- Truncated isoforms of GPSM2 containing the GoLoco motif region promote CD4Lupus science & medicine · 2022Article
- IL-17-producing follicular Th cells enhance plasma cell differentiation in lupus-prone mice.JCI insight · 2022Article
- Review
- Gut dysbiosis is associated with acceleration of lupus nephritis.Scientific reports · 2022Article
- Chronic Active Antibody-Mediated Rejection Is Associated With the Upregulation of Interstitial But Not Glomerular Transcripts.Frontiers in immunology · 2021Article
- The Th17/IL-17 Axis and Kidney Diseases, With Focus on Lupus Nephritis.Frontiers in medicine · 2021Review
- Kidney tissue hypoxia dictates T cell-mediated injury in murine lupus nephritis.Science translational medicine · 2020Article
- IL-12 and IL-23/Th17 axis in systemic lupus erythematosus.Experimental biology and medicine (Maywood, N.J.) · 2019Review
- Facilitated expansion of Th17 cells in lupus nephritis patients.Clinical and experimental immunology · 2018Article
- Kidney-infiltrating T cells in murine lupus nephritis are metabolically and functionally exhausted.The Journal of clinical investigation · 2018Article
- Intracapillary immune complexes recruit and activate slan-expressing CD16+ monocytes in human lupus nephritis.JCI insight · 2018Article
- CD4Clinical and experimental immunology · 2018Article
- T cells and autoimmune kidney disease.Nature reviews. Nephrology · 2017Review
- Th17 responses and natural IgM antibodies are related to gut microbiota composition in systemic lupus erythematosus patients.Scientific reports · 2016Article
- Glomerular cytokine expression in murine lupus nephritis.Clinical and experimental nephrology · 2016Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To determine the cytokine balance in patients with lupus nephritis (LN), we analysed kidney-infiltrating T cells. Renal biopsy samples from 15 systemic lupus erythematosus (SLE) patients were used. In accordance with the classification of International Society of Nephrology/Renal Pathology Society, they were categorized into Class III, Class III+V (Class III-predominant group, n = 4), Class IV, Class IV+V (Class IV-predominant group, n = 7) and Class V (n = 4) groups. The single-cell samples of both the glomelular and interstitial infiltrating cells were captured by laser-microdissection. The glomerular and interstitial infiltrating T cells produced interleukin (IL)-2, IL-4, IL-10, IL-13 and IL-17 cytokines in the Class III-predominant, Class IV-predominant and Class V groups. Interferon-gamma was detected only in the glomeruli of the Class III-predominant and Class V group samples. The expression level of IL-17 was correlated closely with clinical parameters such as haematuria, blood urea nitrogen level, SLE Disease Activity Index scores in both glomeruli and interstitium, urine protein level in glomeruli and serum creatinine and creatinine clearance levels in interstitium. This suggests that the glomerular infiltrating T cells might act as T helper type 1 (Th1), Th2 and Th17 cells while the interstitial infiltrating T cells, act as Th2 and Th17 cells in the Class III-predominant and Class V groups. In contrast, both the glomerular and interstitial infiltrating T cells might act as Th2 and Th17 cells in the Class IV-predominant group. The cytokine balances may be dependent upon the classification of renal pathology, and IL-17 might play a critical role in SLE development.
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