ArticleThe Journal of membrane biology2009
Optical coherence tomography phase measurement of transient changes in squid giant axons during activity.
Article in The Journal of membrane biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Spark or Sound: How Two Differing Explanatory Strategies Impact the Debate on the Physical Nature of Neuronal Excitability.Membranes · 2026Article
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- All-optical observation on activity-dependent nanoscale dynamics of myelinated axons.Neurophotonics · 2023Article
- Analysis of outer hair cell electromechanics reveals power delivery at the upper-frequency limits of hearing.Journal of the Royal Society, Interface · 2022Article
- Ultra-parallel label-free optophysiology of neural activity.iScience · 2022Article
- On the Coupling between Mechanical Properties and Electrostatics in Biological Membranes.Membranes · 2021Review
- The optoretinogram reveals the primary steps of phototransduction in the living human eye.Science advances · 2020Article
- High-speed interferometric imaging reveals dynamics of neuronal deformation during the action potential.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Measurement and visualization of stimulus-evoked tissue dynamics in mouse barrel cortex using phase-sensitive optical coherence tomography.Biomedical optics express · 2020Article
- Simulating optical coherence tomography for observing nerve activity: A finite difference time domain bi-dimensional model.PloS one · 2018Article
- Full-field interferometric imaging of propagating action potentials.Light, science & applications · 2018Article
- Label-free optical detection of action potential in mammalian neurons.Biomedical optics express · 2017Article
- OCT intensity and phase fluctuations correlated with activity-dependent neuronal calcium dynamics in theBiomedical optics express · 2017Article
- Acoustic neuromodulation from a basic science prospective.Journal of therapeutic ultrasound · 2016Review
- Fourier phase in Fourier-domain optical coherence tomography.Journal of the Optical Society of America. A, Optics, image science, and vision · 2015Article
- Optical coherence tomography for cross-sectional imaging of neural activity.Neurophotonics · 2015Article
- Nonsynaptic and nonvesicular ATP release from neurons and relevance to neuron-glia signaling.Seminars in cell & developmental biology · 2011Review
- Signaling by neuronal swelling.Science signaling · 2011Article
- Intrinsic optical signal imaging of glucose-stimulated insulin secreting β-cells.Optics express · 2011Article
- Imaging single photons and intrinsic optical signals for studies of vesicular and non-vesicular ATP release from axons.Frontiers in neuroanatomy · 2011Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Noncontact optical measurements reveal that transient changes in squid giant axons are associated with action potential propagation and altered under different environmental (i.e., temperature) and physiological (i.e., ionic concentrations) conditions. Using a spectral-domain optical coherence tomography system, which produces real-time cross-sectional images of the axon in a nerve chamber, axonal surfaces along a depth profile are monitored. Differential phase analyses show transient changes around the membrane on a millisecond timescale, and the response is coincident with the arrival of the action potential at the optical measurement area. Cooling the axon slows the electrical and optical responses and increases the magnitude of the transient signals. Increasing the NaCl concentration bathing the axon, whose diameter is decreased in the hypertonic solution, results in significantly larger transient signals during action potential propagation. While monophasic and biphasic behaviors are observed, biphasic behavior dominates the results. The initial phase detected was constant for a single location but alternated for different locations; therefore, these transient signals acquired around the membrane appear to have local characteristics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.